Two types of neurons in the primate globus pallidus external segment play distinct roles in antisaccade generation.
Two types of neurons in the primate globus pallidus external segment play distinct roles in antisaccade generation.
复制标题
灵长类苍白球外节中的两种类型的神经元在抗眼跳生成中发挥着不同的作用。
DOI：
10.1093/cercor/bhu308
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
M.
中科院分区：
文献类型：
--
作者：
Yoshida;A. & Tanaka;M.
苍白球外段（GPe）构成基底神经节间接通路的一部分。由于纹状体的抑制性投射，预计大多数GPe神经元在运动期间会减少活动。然而，许多GPe神经元实际上显示出增加的活性。我们以前发现，兴奋性和抑制性反应的调制过程中antisaccades，当眼睛被定向远离视觉刺激。为了阐明这些神经元在antisaccades过程中的作用，我们研究了猴子在2种条件下执行antisaccades，prosaccades和NoGo任务时的神经元活动。在刻意条件下，任务规则由注视点的颜色指示，而在即时条件下，任务规则由目标的颜色指示。在这两种情况下，增加型神经元表现出更大的活动，在反扫视相比，与其他任务和神经元的活动与扫视潜伏期呈负相关。下降型神经元也表现出更大的调制过程中antisaccades，但他们的活动之间的NoGo和antisaccade试验中的即时条件。这些结果表明，增加型神经元可能在促进反扫视中起作用，而减少型神经元可能介导反射性扫视抑制信号。我们建议，这些GPe神经元不同地参与基底神经节通路。
The globus pallidus external segment (GPe) constitutes part of the indirect pathway of the basal ganglia. Because of inhibitory projections from the striatum, most GPe neurons are expected to reduce activity during movements. However, many GPe neurons in fact display increased activity. We previously found that both excitatory and inhibitory responses were modulated during antisaccades, when eyes were directed away from a visual stimulus. To elucidate the roles of these neurons during antisaccades, we examined neuronal activities as monkeys performed antisaccades, prosaccades, and NoGo tasks under 2 conditions. In the Deliberate condition, the task-rule was instructed by color of the fixation point, while in the Immediate condition, it was given by color of the target. Under both conditions, the increase-type neurons exhibited greater activity during antisaccades compared with the other tasks and neuronal activity negatively correlated with saccade latency. The decrease-type neurons also showed greater modulation during antisaccades but their activity was comparable between NoGo and antisaccade trials in the Immediate condition. These results suggest that the increase-type neurons might play a role in facilitating antisaccades, whereas the decrease-type neurons could mediate signals for reflexive saccade suppression. We propose that these GPe neurons are differently involved in basal ganglia pathways.