Computer modeling approach for micro sphere-packed bone scaffold
Computer modeling approach for micro sphere-packed bone scaffold
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DOI：
10.1016/s0010-4485(03)00134-9
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发表时间：
2004-04-15
影响因子：
4.3
通讯作者：
Sun, W
中科院分区：
文献类型：
--
作者：
Lal, P;Sun, W
提出了一种构建三维微球填充骨移植结构的计算机建模方法。建模方法包括几何建模和基于cad的计算机建模。几何模型采用两种极端微球填充模型（最小密度填充和最大密度填充）和统计填充模型来确定合成骨移植物中填充的微球数量。对填充内孔结构的孔径进行了预测，并对微球直径对微球数和孔径的影响进行了参数化研究。在此基础上，提出了一种设计随机微球填充三维骨移植体的CAD建模方法。介绍了CAD模型的层次结构和构建骨移植模型的步骤，并介绍了基于CAD的骨移植模型在内部结构检查、可视化、预测以及与体外骨长入比较中的应用。(C) 2003 Elsevier Ltd.版权所有。
A computer modeling approach for constructing a three-dimensional microsphere-packed bone graft structure is presented. The modeling approach consists of both geometric and CAD-based computer modeling. The geometric model uses two extreme microsphere packing models (mini mum-density packing and maximum-density packing) and a statistical packing model to determine the number of microspheres packed in a synthesized bone graft. The pore size of the packed internal porous structure is predicted, and a parametric study of the effect of microsphere diameter on the number of microspheres and pore size is conducted. Based on the results obtained from the geometric model, a CAD modeling approach for designing randomly microsphere-packed three-dimensional bone grafts was developed. The hierarchy of the CAD model and the steps for constructing a bone graft model are described, and application of the CAD-based bone graft model in internal structural examination, visualization, prediction and comparison with in vitro bone ingrowth is presented. (C) 2003 Elsevier Ltd. All rights reserved.