Wnt Signaling Pathways: A Role in Pain Processing.
Wnt Signaling Pathways: A Role in Pain Processing.
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DOI：
10.1007/s12017-021-08700-z
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发表时间：
2022-09
影响因子：
3.5
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中科院分区：
文献类型：
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无翅相关整合位点（Wnt）信号通路在胚胎发育和神经系统调控中起重要作用。它参与多种类型的神经性疼痛（NP），如hiv相关NP、癌症疼痛、糖尿病神经痛、多发性硬化症相关NP、子宫内膜异位症疼痛和其他疼痛性疾病。Wnt信号也与坐骨神经压迫损伤和选择性脊神经结扎引起的疼痛有关。因此，Wnt信号通路可能是NP的潜在治疗靶点。
The wingless-related integration site (Wnt) signaling pathway plays an essential role in embryonic development and nervous system regulation. It is critically involved in multiple types of neuropathic pain (NP), such as HIV-related NP, cancer pain, diabetic neuralgia, multiple sclerosis-related NP, endometriosis pain, and other painful diseases. Wnt signaling is also implicated in the pain induced by sciatic nerve compression injury and selective spinal nerve ligation. Thus, the Wnt signaling pathway may be a potential therapeutic target for NP.