Composite renal cell carcinoma and angiomyolipoma: A study of the histogenetic relationship of the two lesions
Composite renal cell carcinoma and angiomyolipoma: A study of the histogenetic relationship of the two lesions
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复合性肾细胞癌和血管平滑肌脂肪瘤：两种病变组织遗传学关系的研究
DOI：
10.1046/j.1440-1827.1999.00818.x
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发表时间：
1999
影响因子：
2.2
通讯作者：
J. Collins
中科院分区：
文献类型：
--
作者：
K. Mai;D. Garth Perkins;S. Robertson;Jane Thomas;Christopher Morrash;J. Collins
本研究的目的是探讨肾细胞癌（RCC）和血管平滑肌脂肪瘤（AMYL）发生在同一个肾结节的可能的组织遗传学关系，通过检查两例混合RCC和AMYL的患者没有结节性硬化症的痕迹，并通过审查类似案件的医学文献。病例1代表了一个上皮样变异的AMYL与多个额外的结节，典型的AMYL在手术切除的肾脏。患者随后在24个月后腹膜后出现由AMYL和RCC的上皮样变体混合物组成的病变，另外4个月后在肝脏出现病变。RCC细胞类似于上皮样AMYL的单核上皮样细胞，除了它们在腹膜后与上皮膜抗原（EMA）局部反应，在肝脏与EMA和细胞角蛋白（CK）局部反应。病例2是典型的AMYL与嗜色细胞RCC混合。对医学文献的审查显示，另外7例病例的组织病理学结果与该病例相似。所有病例均有典型的多发性AMYL病灶。免疫染色结果可在五个肿瘤。嗜铬细胞癌与CK和EMA的反应性不同。此外，本研究中的两例肾细胞癌也显示粘蛋白染色阳性反应和癌胚抗原阳性反应。在病例1的三个连续标本中，似乎有一系列的组织病理学和免疫组织化学变化，从上皮样AMYL变体到混合上皮样AMYL/RCC到嗜色性RCC。此外，在本研究的两个病例中，以及文献中的其他病例中，AMYL和RCC的紧密混合物以及RCC上皮标志物的相似表达表明，一些RCC是从与AMYL相同的前体细胞或AMYL的组分发展而来的。
The purpose of the present study was to investigate the possible histogenetic relationship of renal cell carcinoma (RCC) and angiomyolipoma (AMYL) occurring in the same renal nodule by examining two cases of composite RCC and AMYL in patients without stigmata of tuberous sclerosis and by reviewing the medical literature of similar cases. Case 1 represents an epithelioid variant of AMYL with multiple additional nodules of typical AMYL in a surgically removed kidney. The patient subsequently developed a lesion consisting of a mixture of epithelioid variant of AMYL and RCC 24 months later in the retroperitoneum and, an additional 4 months later, in the liver. The RCC cells resembled mononucleated epithelioid cells of the epithelioid AMYL except that they were focally reactive with epithelial membrane antigen (EMA) in the retroperitoneum and focally reactive with both EMA and cytokeratin (CK) in the liver. Case 2 consisted of a typical AMYL admixed with a chromophil cell RCC. A review of the medical literature revealed seven additional cases with histopathological findings similar to this case. All cases had multiple foci of typical AMYL. Immunostaining results are available in five tumors. Chromophil RCC showed variable reactivity with CK and EMA. In addition, RCC in the two cases in the present study also displayed a positive reaction with mucin staining and a positive reactivity with carcinoembryonic antigen. There appears to be a spectrum of histopathological and immunohistochemical changes from the epithelioid variant of AMYL through a mixed epithelioid AMYL/RCC to chromophil RCC in three successive specimens in case 1. Moreover, the intimate admixture of AMYL and RCC and the similar expression of epithelial markers of RCC in the two cases in the present study, as well as other cases in the literature, suggest that some RCC develop from the same precursor cell as AMYL or from a component of AMYL.
结节性硬化症相关肾细胞癌。
DOI：
--
发表时间：
1996
期刊：
The American journal of pathology
影响因子：
--
作者：
Bjornsson,J;Short,MP;Kwiatkowski,DJ;Henske,EP
通讯作者：
Henske,EP
雌激素诱导的叙利亚仓鼠肾肿瘤的形态学和免疫组织化学研究：可能的起源细胞。
影响因子：
11.2
作者：
Gonzalez,A;Oberley,TD;Li,JJ
通讯作者：
Li,JJ
叙利亚仓鼠雌激素诱导肿瘤早期肾脏病变的特征。
影响因子：
11.2
作者：
Oberley,TD;Gonzalez,A;Lauchner,LJ;Oberley,LW;Li,JJ
通讯作者：
Li,JJ