Human p53 gene localized to short arm of chromosome 17.
Human p53 gene localized to short arm of chromosome 17.
复制标题
人类 p53 基因定位于 17 号染色体短臂。
作者：
Miller,C;Mohandas,T;Wolf,D;Prokocimer,M;Rotter,V;Koeffler,HP
p53基因编码在正常细胞复制中具有重要作用的核蛋白1 -4。p53蛋白的浓度在转化细胞中经常升高1，2。转染研究表明，p53基因与激活的drasoncogene协同作用，可以转化细胞5 -7。染色体定位可以提供一个更好的理解的关系p53到其他人类细胞基因和它的可能作用与特定的染色体重排的恶性肿瘤。最近的一项研究将人类p53基因定位在染色体长臂上。17（17 q21-q22），使用原位染色体杂交8。在这里，通过Southern滤膜杂交的DNA从人类啮齿动物的杂交，我们已经定位的p53基因的短臂的人类染色体17。
The p53 gene codes for a nuclear protein that has an important role in normal cellular replication1–4. The concentration of p53 protein is frequently elevated in transformed cells1,2. Transfection studies show that the p53 gene, in collaboration with the activatedrasoncogene, can transform cells5–7. Chromosomal localization may provide a better understanding of the relationship of p53 to other human cellular genes and of its possible role in malignancies associated with specific chromosomal rearrangements. A recent study mapped the human p53 gene to the long arm of chromosome. 17 (17q21–q22) usingin situchromosomal hybridization8. Here, by Southern filter hybridization of DNAs from human–rodent hybrids, we have localized the p53 gene to the short arm of human chromosome 17.