The eyes have it: influenza virus infection beyond the respiratory tract
The eyes have it: influenza virus infection beyond the respiratory tract
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DOI：
10.1016/s1473-3099(18)30102-6
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发表时间：
2018-07-01
影响因子：
56.3
通讯作者：
Maines, Taronna R.
中科院分区：
文献类型：
--
作者：
Belser, Jessica A.;Lash, R. Ryan;Maines, Taronna R.
禽流感和人流感A病毒都显示出利用眼睛作为进入门户并引起人类眼部疾病的能力。然而，尽管流感病毒通常代表呼吸道病原体并且仅偶尔引起眼部并发症，但H7病毒亚型在具有眼部嗜性方面是独一无二的。澄清是什么赋予了呼吸道病毒这种非呼吸道嗜性，将允许更大的能力来识别，治疗和预防眼部暴露于流感病毒后的人畜共患感染;特别是那些在H7亚型内的病毒，这些病毒继续在许多大陆引起禽流感。
Avian and human influenza A viruses alike have shown a capacity to use the eye as a portal of entry and cause ocular disease in human beings. However, whereas influenza viruses generally represent a respiratory pathogen and only occasionally cause ocular complications, the H7 virus subtype stands alone in possessing an ocular tropism. Clarifying what confers such non-respiratory tropism to a respiratory virus will permit a greater ability to identify, treat, and prevent zoonotic human infection following ocular exposure to influenza viruses; especially those within the H7 subtype, which continue to cause avian epidemics on many continents.