RENAL CONSERVATION OF TRIMETHYLAMINE OXIDE BY THE SPINY DOGFISH, SQUALUS-ACANTHIAS
RENAL CONSERVATION OF TRIMETHYLAMINE OXIDE BY THE SPINY DOGFISH, SQUALUS-ACANTHIAS
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DOI：
10.1152/ajplegacy.1958.194.2.229
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发表时间：
1958-01-01
影响因子：
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通讯作者：
CHIDSEY, CA
中科院分区：
文献类型：
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作者：
COHEN, JJ;KRUPP, MA;CHIDSEY, CA
研究发现角鲨体内的三甲胺氧化物 (Oxide) 血浆浓度维持在 60-80 u mol/ml 的狭窄范围内。尽管禁食时间较长（长达 41 天），这些水平仍能维持。氧化物可在肾小球自由过滤，但会被肾小管大量重吸收。因此，小于 10% 的过滤氧化物出现在尿液中。角鲨尿液中被发现含有一种不明的挥发性胺，而不是 NH3，推测是三甲胺。讨论了氧化物在软骨鱼类生理学中的可能作用。
Trimethylamine oxide (Oxide) plasma concentrations in the dogfish have been found to be maintained within the narrow range of 60-80 u mol/ml. These levels are maintained in spite of prolonged (up to 41 days) fasting. The Oxida is freely filterable at the glomerulus but is avidly reabsorbed by the renal tubule. Thus, less than 10% of the filtered Oxide appears in the urine. Dogfish urine has been found to contain an unidentified volatile amine, not NH3, presumed to be trimethylamine. The possible role of the Oxide in elasmobranch physiology is discussed.