CD36 deficiency among South‐East Asian populations
CD36 deficiency among South‐East Asian populations
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东南亚人群中 CD36 缺乏症
DOI：
10.1111/voxs.12261
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
S. Santoso
中科院分区：
文献类型：
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作者：
W. Xia;X. Xu;Y. Fu;X. Ye;N. Tsuno;S. Santoso
免疫介导的血小板减少症通常是由血小板反应性抗体引起的，这些抗体主要针对血小板糖蛋白上的多态性结构，如人白细胞抗原和人血小板抗原（HLA I类和HPA）。在日本人群中，一些个体在细胞表面不表达CD36 （CD36null也称为Naka）。这些个体的免疫可导致CD36同工抗体（抗Naka）的产生，该抗体在血小板输注难耐、输注后紫癜和胎儿/新生儿同种免疫血小板减少症的机制中发挥作用。然而，直到今天，人们对CD36缺乏症和CD36同型抗体在其他东南亚人群中的临床相关性知之甚少。因此，在ISBT的支持下，组织了多国研究，研究CD36缺乏症在该地区的分布。
Immune‐mediated thrombocytopenia is commonly caused by platelet‐reactive antibodies mostly against polymorphic structures residing on platelet glycoproteins such as human leucocyte antigen and human platelet antigen (HLA class I and HPA). In the Japanese population, some individuals do not express CD36 (CD36null also known as Naka) on the cell surface. Immunization of these individuals can lead to the development of CD36 isoantibodies (anti‐Naka) which play a role in the mechanism of platelet transfusion refractoriness, post‐transfusion purpura and fetal/neonatal alloimmune thrombocytopenia. Until today, however, little is known about the clinical relevance of CD36 deficiency and CD36 isoantibodies among other South‐East Asian populations. Therefore, multinational study was organised under the aegis of the ISBT to study the distribution of CD36 deficiency in this region.