Aberrant Gray Matter Volume and Cortical Surface in Paranoid-Type Delusional Disorder
Aberrant Gray Matter Volume and Cortical Surface in Paranoid-Type Delusional Disorder
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DOI：
10.1159/000505601
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发表时间：
2020-07-01
影响因子：
3.2
通讯作者：
Huber, Markus
中科院分区：
文献类型：
--
作者：
Wolf, Robert Christian;Hildebrandt, Viviane;Huber, Markus
简介：精神分裂症是精神分裂症谱系和相关疾病的核心症状。尽管它们具有临床意义，但这些现象背后的神经相关性尚不清楚。最近的研究表明，特定的妄想内容可能与不同的神经substrate.Objective：在这里，我们使用结构磁共振成像，以探讨多个参数的大脑形态的偏执型妄想障碍（pt-DD，n= 14）的患者相比，健康对照组（HC，n= 25）。方法：体素和表面为基础的形态结构数据被用来调查灰质体积（GMV），皮质厚度（CT）和gyrifiation.Results：相比，HC，患者与pt-DD显示减少GMV在双侧杏仁核和右额下回。患者双侧眶额皮质和左侧上级额叶皮质GMV较高。患者的额部和颞部CT也较低。异常gyrification的患者是明显的，在额叶和颞叶地区，以及在双边cross.Conclusions：数据表明存在异常的GMV在右前额叶区域与信念评估，以及不同的结构异常，基本上是subserve处理的恐惧，焦虑和威胁的患者PT-DD。这是可能的，不同的进化和遗传起源的皮质功能，即CT和脑回，有助于不同的发病机制的pt-DD。
Introduction:Delusions are core symptoms of schizophrenia-spectrum and related disorders. Despite their clinical relevance, the neural correlates underlying such phenomena are unclear. Recent research suggests that specific delusional content may be associated with distinct neural substrates.Objective:Here, we used structural magnetic resonance imaging to investigate multiple parameters of brain morphology in patients presenting with paranoid type delusional disorder (pt-DD,n= 14) compared to those of healthy controls (HC,n= 25).Methods:Voxel- and surface-based morphometry for structural data was used to investigate gray matter volume (GMV), cortical thickness (CT) and gyrification.Results:Compared to HC, patients with pt-DD showed reduced GMV in bilateral amygdala and right inferior frontal gyrus. Higher GMV in patients was found in bilateral orbitofrontal and in left superior frontal cortices. Patients also had lower CT in frontal and temporal regions. Abnormal gyrification in patients was evident in frontal and temporal areas, as well as in bilateral insula.Conclusions:The data suggest the presence of aberrant GMV in a right prefrontal region associated with belief evaluation, as well as distinct structural abnormalities in areas that essentially subserve processing of fear, anxiety and threat in patients with pt-DD. It is possible that cortical features of distinct evolutionary and genetic origin, i.e. CT and gyrification, contribute differently to the pathogenesis of pt-DD.