HLA-DR4 subtype and -B alleles in DQB1*0302-positive haplotypes associated with IDDM. The Childhood Diabetes in Finland Study Group.
HLA-DR4 subtype and -B alleles in DQB1*0302-positive haplotypes associated with IDDM. The Childhood Diabetes in Finland Study Group.
复制标题
与 IDDM 相关的 DQB1*0302 阳性单倍型中的 HLA-DR4 亚型和 -B 等位基因。
DOI：
10.1046/j.1365-2370.1997.d01-108.x
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Ilonen,J
中科院分区：
文献类型：
--
作者：
Reijonen,H;Nejentsev,S;Tuokko,J;Koskinen,S;Tuomilehto-Wolf,E;Akerblom,HK;Ilonen,J
我们确定了在胰岛素依赖型糖尿病（IDDM）患者中发现的309个DQB 1 *0302阳性单倍型和仅存在于健康家庭成员中的70个对照单倍型中DR 4亚型的分布。DRB 1 *0401等位基因频率升高（74.4%比55.7%，P = 0.003），DRB 1 *0404等位基因频率降低（23.6%比40.0%，P = 0.0064）。对扩展单倍型的进一步分析表明，各种B等位基因和DRB 1 *04亚型之间存在强连锁。与对照组相比，DRB 1 *0404-DQB 1 *0302阳性单倍型中HLA-B39的频率更高（37.0%vs.14.3%，P = 0.049），提示HLA-DRB 1端粒区参与了IDDM的易感性。
We determined the distribution of DR4 subtypes in 309 DQB1*0302‐positive haplotypes found in insulin‐dependent diabetes mellitus (IDDM) patients and 70 control haplotypes present only in healthy family members. An increased frequency of DRB1*0401 allele (74.4% vs. 55.7%,P= 0.003) and a decrease of DRB1*0404 allele (23.6% vs. 40.0%,P= 0.0064) was revealed. A further analysis of extended haplotypes demonstrated strong linkages between various B alleles and DRB1*04 subtypes. HLA‐B39 was more frequent in DRB1*0404–DQB1*0302‐positive IDDM haplotypes compared with control ones (37.0% vs. 14.3%,P= 0.049), suggesting an involvement of the region telomeric to HLA‐DRB1 in the susceptibility to IDDM.