Association between inflammatory-related disease burden and frailty: Results from the Women's Health and Aging Studies (WHAS) I and II
Association between inflammatory-related disease burden and frailty: Results from the Women's Health and Aging Studies (WHAS) I and II
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DOI：
10.1016/j.archger.2011.05.020
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发表时间：
2012-01-01
影响因子：
4
通讯作者：
Fried, Linda P.
中科院分区：
文献类型：
--
作者：
Chang, Sandy S.;Weiss, Carlos O.;Fried, Linda P.
虚弱与促炎状态相关，其特征在于全身炎症生物标志物水平升高，但与炎症相关的共存慢性疾病的数量无关。我们试图确定更多炎症相关疾病与虚弱相关的程度，并确定与老年人虚弱相关的最常见疾病模式。我们进行了二项回归分析，以评估是否更高的炎症相关疾病的计数增加脆弱的可能性，使用的数据从WHAS I和II，同伴队列组成的70-79岁的社区居住的老年妇女在巴尔的摩，马里兰州（n = 620）。一种炎症相关疾病的增加与虚弱呈对数线性相关（患病率比（PR）= 2.28，95%置信区间（CI）= 1.81-2.87）。校正年龄、种族、教育和吸烟状况后，虚弱的概率仍然显著（PR = 1.97，95%CI = 1.52-2.55）。在体弱人群中，慢性肾病（CKD）和抑郁症状（患病率= 22.9%，95%CI = 14.2-34.8%）; CVD和抑郁症状（21.7%，95%CI = 13.2-33.5%）; CKD和贫血（18.7%，95%CI = 11.1-29.7%）;心血管疾病（CVD）、CKD和肺部疾病（10.7%，95%CI = 5.2-21.0%）; CKD、贫血和抑郁症状（8.7%，95%CI = 3.9-18.2%）; CVD、贫血、肺部疾病和抑郁症状（5.0%，95%CI = 1.6-14.4%）是最常见的疾病组合。他们的患病率百分比显着高于体弱与非体弱的妇女。较高的炎症相关疾病计数，可能反映了更大的促炎负担，增加了虚弱的可能性。特定疾病组合之间的共同机制可能进一步导致这种风险。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
Frailty is associated with a pro-inflammatory state, which has been characterized by elevated levels of systemic inflammatory biomarkers, but has not been related to the number of co-existing chronic diseases associated with inflammation. We sought to determine the extent to which a higher number of inflammatory-related diseases is associated with frailty and to identify the most common disease patterns associated with being frail in older adults. We performed binomial regression analyses to assess whether a higher count of inflammatory-related diseases increases the probability of frailty using data from the WHAS I and II, companion cohorts composed of 70-79-year-old community-dwelling older women in Baltimore, Maryland (n = 620). An increase of one inflammatory-related disease was associated log-linearly with frailty (Prevalence Ratio (PR) = 2.28, 95% Confidence Interval (CI) = 1.81-2.87). After adjusting for age, race, education, and smoking status, the probability of frailty remained significant (PR = 1.97, 95%CI = 1.52-2.55). In the frail population, chronic kidney disease (CKD) and depressive symptoms (Prevalence = 22.9%, 95%CI = 14.2-34.8%); CVD and depressive symptoms (21.7%, 95%CI = 13.2-33.5%); CKD and anemia (18.7%, 95%CI = 11.1-29.7%); cardiovascular disease (CVD), CKD, and pulmonary disease (10.7%, 95%CI = 5.2-21.0%); CKD, anemia, and depressive symptoms (8.7%, 95%CI = 3.9-18.2%); and CVD, anemia, pulmonary disease, and depressive symptoms (5.0%, 95%CI = 1.6-14.4%) were among the most frequent disease combinations. Their prevalence percentages were significantly higher in the frail versus non-frail women. A higher inflammatory-related disease count, perhaps reflecting a greater pro-inflammatory burden, increases the likelihood of frailty. Shared mechanisms among specific disease combinations may further contribute to this risk. (C) 2011 Elsevier Ireland Ltd. All rights reserved.