Cryptochrome-dependent magnetic field effect on seizure response in Drosophila larvae.
Cryptochrome-dependent magnetic field effect on seizure response in Drosophila larvae.
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DOI：
10.1038/srep05799
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发表时间：
2014-07-23
影响因子：
4.6
通讯作者：
Jones AR
中科院分区：
文献类型：
--
作者：
Marley R;Giachello CN;Scrutton NS;Baines RA;Jones AR
几十年来，促进动物磁感受的机制让科学家们既着迷又困惑，其确切的生物物理起源仍不清楚。在提出的主要磁传感器中，黄素蛋白隐花色素被认为是通过光引发的自由基对反应中的量子效应提供地磁信息。尽管最近在理论、分子和动物行为研究中对磁接受的自由基对模型取得了进展，但对可能的信号转导机制知之甚少。我们报告了磁场暴露对果蝇幼虫癫痫反应的实质性影响。这种效果取决于隐花色素、光的存在和波长，并被先前摄入的典型抗癫痫药物所阻断。这些数据与隐花色素中改变神经元兴奋水平的磁敏感、光化学自由基对反应相一致，并代表着我们对动物磁接受的信号转导机制的理解向前迈出了重要的一步。
The mechanisms that facilitate animal magnetoreception have both fascinated and confounded scientists for decades, and its precise biophysical origin remains unclear. Among the proposed primary magnetic sensors is the flavoprotein, cryptochrome, which is thought to provide geomagnetic information via a quantum effect in a light-initiated radical pair reaction. Despite recent advances in the radical pair model of magnetoreception from theoretical, molecular and animal behaviour studies, very little is known of a possible signal transduction mechanism. We report a substantial effect of magnetic field exposure on seizure response in Drosophila larvae. The effect is dependent on cryptochrome, the presence and wavelength of light and is blocked by prior ingestion of typical antiepileptic drugs. These data are consistent with a magnetically-sensitive, photochemical radical pair reaction in cryptochrome that alters levels of neuronal excitation, and represent a vital step forward in our understanding of the signal transduction mechanism involved in animal magnetoreception.
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影响因子：
9.8
作者：
Yoshii T;Ahmad M;Helfrich-Förster C
通讯作者：
Helfrich-Förster C
影响因子：
2.9
作者：
Selby, Christopher P.;Sancar, Aziz
通讯作者：
Sancar, Aziz
DOI：
10.1523/jneurosci.6042-11.2012
发表时间：
2012-05-23
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Lin WH;Günay C;Marley R;Prinz AA;Baines RA
通讯作者：
Baines RA
DOI：
10.1073/pnas.1313336110
发表时间：
2013-12-17
影响因子：
11.1
作者：
Vaidya, Anand T.;Top, Deniz;Crane, Brian R.
通讯作者：
Crane, Brian R.
影响因子：
3.9
作者：
Woodward, Jonathan R.;Foster, Timothy J.;Scrutton, Nigel S.
通讯作者：
Scrutton, Nigel S.