Investigation of outer cortical magnetisation transfer ratio abnormalities in multiple sclerosis clinical subgroups
Investigation of outer cortical magnetisation transfer ratio abnormalities in multiple sclerosis clinical subgroups
复制标题
DOI：
10.1177/1352458514522537
复制
发表时间：
2014-09-01
影响因子：
5.8
通讯作者：
Chard, Declan T.
中科院分区：
文献类型：
--
作者：
Samson, Rebecca S.;Cardoso, Manuel J.;Chard, Declan T.
背景资料：多发性硬化症（MS）患者的外皮层存在脱髓鞘和神经元丢失等病理异常。目的：通过测量不同亚组MS患者的磁化传递率（MTR），研究外皮层异常的体内证据。44例复发缓解型（RR）（平均年龄41.9岁，中位扩展残疾状态量表（EDSS）2.0），25次进行性（SP）研究了19名原发性进展性（PP）（53.1岁，EDSS 6.0）MS患者和35名健康对照受试者（平均年龄39.2岁）。采集三维（3D）1x 1x 1 mm（3）T-1加权图像和MTR数据。结果：在成对分析中，所有MS组和对照组的平均外皮质MTR均低于平均内皮质MTR（P
Background: Pathological abnormalities including demyelination and neuronal loss are reported in the outer cortex in multiple sclerosis (MS).Objective: We investigated for in vivo evidence of outer cortical abnormalities by measuring the magnetisation transfer ratio (MTR) in MS patients of different subgroups.Methods: Forty-four relapsing-remitting (RR) (mean age 41.9 years, median Expanded Disability Status Scale (EDSS) 2.0), 25 secondary progressive (SP) (54.1 years, EDSS 6.5) and 19 primary progressive (PP) (53.1 years, EDSS 6.0) MS patients and 35 healthy control subjects (mean age 39.2 years) were studied. Three-dimensional (3D) 1x1x1mm(3) T-1-weighted images and MTR data were acquired. The cortex was segmented, then subdivided into outer and inner bands, and MTR values were calculated for each band.Results: In a pairwise analysis, mean outer cortical MTR was lower than mean inner cortical MTR in all MS groups and controls (p