Prevalence of open-angle glaucoma in Australia - The Blue Mountains eye study
Prevalence of open-angle glaucoma in Australia - The Blue Mountains eye study
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DOI：
10.1016/s0161-6420(96)30449-1
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发表时间：
1996-10-01
期刊：
影响因子：
13.7
通讯作者：
Healey, PR
中科院分区：
文献类型：
--
作者：
Mitchell, P;Smith, W;Healey, PR
目的：本研究的目的是为了确定开角型青光眼和高眼压在一个澳大利亚社区的患病率，该社区的居民年龄在49岁或以上。通过挨家挨户的人口普查和全国人口普查结果的密切匹配来确定人群。方法：所有参与者都接受了详细的眼科检查，包括平压眼压、阈值上自动视野(Humphrey 76点测试)和蔡司立体视盘摄影。青光眼嫌疑人被要求返回进行全阈值视野(Humphrey 30-2测试)、房角镜和重复眼压测量。结果：在76分测试中，616人(19%的受试者)被发现存在5点半视野差异。对336名青光眼可疑患者(占总人口的9.2%)进行了Humphrey 30-2测试，其中125人有典型的青光眼视野缺陷。203人的杯盘比增大或不对称(1只眼或双眼大于或等于0.7，或杯盘比差大于或等于0.3)。开角型青光眼的诊断是当青光眼30-2测试中的青光眼缺陷与视盘变化相匹配时，而不考虑眼压水平。在87名参与者(2.4%)中发现了这种一致性，而另有21人(0.6%)有开角型青光眼的临床症状，但检查结果不完整。因此，在108人中发现了开角型青光眼，患病率为3.0%(95%可信区间[CI]，2.5-3.6)，其中49%以前诊断过。随着年龄的增长，患病率呈指数上升。该人群中3.7%(95%可信区间，3.1-4.3)存在高眼压，定义为双眼眼压高于21毫米汞柱，无视盘和视野改变，但患病率没有明显的年龄相关性增加。调整年龄因素后，女性青光眼患病率更高(优势比，1，5，CI，1.0-2.2)。年龄调整后的眼压患病率没有性别差异。结论：这些数据提供了澳大利亚老年人群中开角型青光眼和高眼压的详细年龄和性别患病率。
Purpose: The purpose of this study was to determine the prevalence of open-angle glaucoma and ocular hypertension in an Australian community whose residents are 49 years of age or older.Subjects: There were 3654 persons, representing 82.4% of permanent residents from an area west of Sydney, Australia, who were examined. The population was identified by a door-to-door census of all dwellings and by closely matched findings from the national census.Methods: All participants received a detailed eye examination, including applanation tonometry, suprathreshold automated perimetry (Humphrey 76-point test), and Zeiss stereoscopic optic disc photography. Glaucoma suspects were asked to return for full threshold fields (Humphrey 30-2 test), gonioscopy, and repeat tonometry.Results: A 5-point hemifield difference on the 76-point test was found in 616 persons (19% of people tested). Humphrey 30-2 tests were performed on 336 glaucoma suspects (9.2% of population), of whom 125 had typical glaucomatous field defects. Two hundred three persons had enlarged or asymmetric cup-disc ratios (greater than or equal to 0.7 in 1 or both eyes or a cup-disc ratio difference of greater than or equal to 0.3). Open-angle glaucoma was diagnosed when glaucomatous defects on the 30-2 test matched the optic disc changes, without regard to the intraocular pressure level. This congruence was found in 87 participants (2.4%), whereas an additional 21 persons (0.6%) had clinical signs of open-angle glaucoma but incomplete examination findings. Open-angle glaucoma was thus found in 108 persons, a prevalence of 3.0% (95% confidence interval [CI], 2.5-3.6), of whom 49% were diagnosed previously. An exponential rise in prevalence was observed with increasing age. Ocular hypertension, defined as an intraocular pressure in either eye greater than 21 mmHg, without matching disc and field changes, was present in 3.7% of this population (95% CI, 3.1-4.3), but there was no significant age-related increase in prevalence. The prevalence of glaucoma was higher in women after adjusting for age (odds ratio, 1,5, CI, 1.0-2.2). There was no sex difference in the age-adjusted prevalence of ocular hypertension.Conclusions: These data provide detailed age and sex-specific prevalence rates for open-angle glaucoma and ocular hypertension in an older Australian population.