Pubertal exposure to estrogenic chemicals affects behavior in juvenile and adult male rats
Pubertal exposure to estrogenic chemicals affects behavior in juvenile and adult male rats
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DOI：
10.1016/j.yhbeh.2006.03.015
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发表时间：
2006-08-01
影响因子：
3.5
通讯作者：
Farabollini, Francesca
中科院分区：
文献类型：
--
作者：
Della Seta, Daniele;Minder, Isabelle;Farabollini, Francesca
本研究探讨了不同来源的雌激素对雄性大鼠社会性行为发育的影响。青春期被认为是个体发育时期的第二阶段，处于哺乳动物性成熟中，对性腺激素特别敏感的环境。我们从出生后第23天到第30天，用环境相容剂量的双酚A对动物进行口服治疗（BPA，40 μ g/kg/天）和一剂炔雌醇（EE，0.4 μ g/kg/天）与人类口服避孕药相当。暴露于EE改变了成年动物雄性性活动的时间模式，降低了性能;用BPA观察到相同方向的轻微改变。在BPA和EE处理的动物中观察到短期行为效应：针对刺激对象和环境以及同种动物的探索性驱动力在青少年中减少。处理后观察到循环T水平的变化：BPA和EE均降低了青少年的T。成年动物的减少持续存在，但仅在BPA组中达到显著性。总的来说，青春期暴露于EE对行为的影响比BPA更显著。这可能是由于EE具有更高的雌激素效力;然而，与EE相比，BPA的行为影响方向表明了雌激素机制。(c)2006年爱思唯尔公司All rights reserved.
In this paper, we tested the hypothesis that exposure to estrogens of different source and estrogenic potency at early puberty could affect the development of socio-sexual behavior in the male rat. Puberty is regarded as a second stage of the ontogenetic period, in the sexual maturation of mammals, particularly sensitive to gonadal hormone milieu. We treated animals orally, from postnatal day 23 to 30, with an environmentally compatible dose of bisphenol A (BPA, 40 mu g/kg/day) and with a dosage of ethinylestradiol (EE, 0.4 mu g/kg/day) comparable to the human oral contraceptives.Exposure to EE altered the temporal pattern of male sexual activity, reducing performance, in the adult animals; slight modifications, in the same direction, were observed with BPA. Short-term behavioral effects were observed in the treated animals, both with BPA and EE: the exploratory drive, directed to a stimulus object and to the environment, as well as to conspecifics, was reduced in the juveniles.Modifications in the circulating T levels were observed after treatments: T was reduced in the juveniles, both with BPA and EE. The decrement persisted in the adult animals but reached significance only in the BPA group.On the whole, effects of pubertal exposure on behavior are more marked with EE than BPA. This can be due to the much higher estrogenic potency of EE; the direction of the behavioral effects of BPA, compared with EE, is however indicative of an estrogenic mechanism. (c) 2006 Elsevier Inc. All rights reserved.