Combinations of radioprotectants spare radiation-induced damage to the physis.
Combinations of radioprotectants spare radiation-induced damage to the physis.
复制标题
辐射防护剂的组合可以避免辐射对身体造成的损害。
DOI：
10.1097/01.blo.0000131247.18112.0f
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发表时间：
2004
影响因子：
4.2
通讯作者：
Farnum,CorneliaE
中科院分区：
文献类型：
--
作者：
Damron,TimothyA;Spadaro,JosephA;Horton,JasonA;Margulies,BryanS;Strauss,JudithA;Farnum,CorneliaE
用于治疗儿科患者骨和软组织肉瘤的放射疗法通常会导致生长板损伤。放射防护剂可能有望在这种情况下选择性保护生长板组织。在动物模型中，测试的假设是，己酮可可碱、硒或米索前列醇与氨磷汀联合使用，与仅使用氨磷汀提供的保护相比，可在更大程度上显着减少一次辐射剂量暴露期间的纵向生长损失，且不会增加发病率或死亡率或对骨矿物质密度产生不利影响。单独使用氨磷汀以及与其他每种辐射防护剂联合使用可使肢体差异减少至显着低于辐射对照的水平。硒和氨磷汀组的胫骨长度差异为12.1±0.8%，小于单独使用氨磷汀治疗的动物的15.5±2.6%的胫骨长度差异，并且低于无辐射防护的受辐射肢体的平均18.8%的胫骨长度差异。任何组中的骨密度均未出现不良影响，但硒和氨磷汀组的死亡率有所增加。氨磷汀与这些辐射防护剂的组合显示出生长板辐射防护的功效，因此需要在临床相关的分割模型中进行进一步的研究。
Radiotherapy used in the treatment of bone and soft tissue sarcomas in pediatric patients often results in undesirable growth plate damage. Radioprotectants may hold promise in the selective protection of growth plate tissue in this setting. In an animal model, the hypothesis tested was that pentoxifylline, selenium, or misoprostol, used in combination with amifostine, would significantly reduce longitudinal growth loss during one radiation dose exposure to a greater extent than the protection provided by only amifostine without increased morbidity or mortality or adverse effects on bone mineral density. Amifostine alone and in combination with each of the other radioprotectants resulted in limb discrepancy reduction to levels significantly less than radiated controls. The tibial length discrepancy in the selenium and amifostine group was 12.1±0.8%, less than the 15.5±2.6% tibial length discrepancy in the animals treated with amifostine alone, and less than the mean 18.8% tibial length discrepancy in the radiated limbs without radioprotection. There were no adverse effects on bone density in any group, but the selenium and amifostine group showed some increased mortality. Combinations of amifostine with these radioprotectants show efficacy in growth plate radioprotection and therefore warrant additional study in a clinically relevant fractionated model.