The toxicology of interleukin-12: A review
The toxicology of interleukin-12: A review
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DOI：
10.1177/019262339902700112
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发表时间：
1999-01-01
影响因子：
1.5
通讯作者：
Anderson, TD
中科院分区：
文献类型：
--
作者：
Car, BD;Eng, VM;Anderson, TD
重组小鼠白细胞介素（IL）-12（rmIL-12）具有抗肿瘤、抗病毒和抗菌活性，并可改善动物模型中的过敏性炎症反应。重组人IL-12（rhIL-12）目前正在临床试验中，用于治疗癌症、哮喘。和病毒性肝炎。IL-12主要是吞噬细胞衍生的细胞因子，靶向自然杀伤细胞和T淋巴细胞，刺激它们的活性和干扰素（IFN）-γ的分泌。对IL-12的毒理学的理解，部分是由于IFN-γ介导的作用，已经从临床前安全性和机制研究以及初始临床试验中出现。几种动物和人类共有的靶器官包括淋巴造血系统、肠、肝和肺。
Recombinant murine interleukin (IL)-12 (rmIL-12) exhibits antitumor, antiviral, and antimicrobial activities and can modify allergic inflammatory reactions in animal models. Recombinant human IL-12 (rhIL-12) is currently in clinical trials for treatment of cancer, asthma. and viral hepatitis. Principally a phagocyte-derived cytokine, IL-12 targets natural killer cells and T lymphocytes, stimulating their activity and the secretion of interferon (IFN)-gamma. An understanding of the toxicology of IL-12, due in part to effects mediated by IFN-gamma, has emerged from preclinical safety and mechanistic studies and initial clinical trials. Target organs common to several animal species and humans include the lymphohematopoietic system, intestines, liver, and lung.