Neuromyelitis optica: a demyelinating disease characterized by acute destruction and regeneration of perivascular astrocytes
Neuromyelitis optica: a demyelinating disease characterized by acute destruction and regeneration of perivascular astrocytes
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DOI：
10.1177/1352458510382324
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发表时间：
2010-10-01
影响因子：
5.8
通讯作者：
Prineas, John W.
中科院分区：
文献类型：
--
作者：
Parratt, John D. E.;Prineas, John W.
目的：探讨多发性硬化症(MS)中是否存在星形胶质细胞病变及其与多发性硬化(MS)星形胶质细胞病变的不同。方法：采用免疫组织化学和常规组织学染色方法，对早期(仍有髓鞘)病变和亚急性NMO和MS病变的星形胶质细胞病理改变进行观察。结果：早期NMO病变脱髓鞘伴随少突胶质细胞凋亡，其方式与MS相同，且在此之前血管周围星形胶质细胞突然破坏。修复性星形胶质细胞增生症受单极新生星形胶质细胞群的影响。在多发性硬化症中发现了一种不同类型的星形胶质细胞损害的证据。讨论：这一发现增加了该抗体具有致病性的实验证据。他们还提出了MS脱髓鞘可能是星形胶质细胞病变的旁观者效应的可能性，即MS不是主要由髓鞘和少突胶质细胞引起的疾病。
Objective: To determine whether there is an astrocyte lesion in NMO and if this differs from astrocyte changes in multiple sclerosis (MS).Methods: Astrocyte pathology in early (still-myelinated) lesions and subacute NMO and MS lesions was examined immunohistochemically and in sections stained for astrocytes using routine histological techniques.Results: Demyelination in early NMO lesions is accompanied by oligodendrocyte apoptosis in a pattern identical to that seen in MS and this is preceded by an abrupt destruction of perivascular astrocytes. Reparative astrogliosis is effected by a population of unipolar, new astrocytes. Evidence of a different type of astrocyte lesion was found in MS.Discussion: The findings add to experimental evidence that the antibody is pathogenic. They also raise the possibility that demyelination in MS may be a bystander effect of an astrocyte lesion, i.e. that MS is not a disease primarily of myelin and oligodendrocytes.