Tissue distribution after intravenous dosing of micafungin, an antifungal drug, to rats.
Tissue distribution after intravenous dosing of micafungin, an antifungal drug, to rats.
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给大鼠静脉注射抗真菌药物米卡芬净后的组织分布。
DOI：
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发表时间：
2004
影响因子：
2
通讯作者：
A. Takagi
中科院分区：
文献类型：
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作者：
T. Niwa;Y. Yokota;A. Tokunaga;Y. Yamato;A. Kagayama;Tomoichi Fujiwara;J. Hatakeyama;M. Anezaki;Y. Ohtsuka;A. Takagi
研究了一种新型类棘白菌脂肽抗真菌药米卡芬金（1 mg/kg）在雄性大鼠静脉注射后的组织分布。给药后第一次采样时间（5 min）， Micafungin在肝、肾、肺中的浓度分别是血浆浓度的1.15、1.64、2.58倍，AUC（0-无穷大）分别是血浆浓度的1.61、3.42、2.89倍。这些组织的终末半衰期分别为5.14、4.87和5.31 h，与血浆相当。这些结果表明，米卡芬新在肝脏、肾脏和肺部等组织中分布迅速而适度，并且组织中的浓度与血浆中未改变的药物平行下降。
The tissue distribution after an intravenous dose of micafungin (1 mg/kg), a new echinocandin-like lipopeptide antifungal agent, to male rats was investigated. Micafungin in plasma disappeared biexponentially with a terminal half-life of 5.03 h. Micafungin concentrations in liver, kidney, and lung at the first sampling time (5 min) after dosing were 1.15, 1.64, and 2.58-fold higher than the plasma concentration, and the AUC(0- infinity ) were 1.61, 3.42, and 2.89-fold higher than that for plasma. The terminal half-lives for these tissues were 5.14, 4.87, and 5.31 h, respectively, which were comparable to those for plasma. These results suggest that micafungin distributes rapidly and moderately into tissues such as the liver, kidney, and lungs, and that the concentrations in tissues decreased in parallel with the unchanged drug in plasma.