A combination of follicle stimulating hormone, estradiol and age is associated with the pregnancy outcome for women undergoing assisted reproduction: a retrospective cohort analysis
A combination of follicle stimulating hormone, estradiol and age is associated with the pregnancy outcome for women undergoing assisted reproduction: a retrospective cohort analysis
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卵泡刺激素、雌二醇和年龄的组合与接受辅助生殖的妇女的妊娠结局相关：一项回顾性队列分析
DOI：
10.1007/s11427-018-9322-6
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发表时间：
2019-01-01
影响因子：
9.1
通讯作者：
Huang, Hefeng
中科院分区：
文献类型：
--
作者：
Jiang, Ziru;Jin, Li;Huang, Hefeng
为了探讨卵泡刺激素（FSH）和雌二醇（E2）等基础激素水平以及年龄对接受体外受精和胚胎移植（IVF-ET）女性妊娠结局的影响，我们设计了回顾性队列分析并收集了2014年1月至2017年4月期间接受IVF患者的信息。我们发现，无论年龄如何，年轻女性的妊娠结局都比老年女性好得多。 激素水平。基础 E2 高的年轻女性的妊娠结局会下降，即使她们的 FSH 正常。 FSH 较高的老年女性妊娠结局较差，尤其是 E2 水平升高时。研究结果提示，结合FSH、E2和年龄可以有效预测IVF-ET女性妊娠结局，应鼓励卵巢储备功能低下的不孕女性，尤其是年轻不孕女性尽早尝试辅助生殖。 40岁以后，要根据卵巢功能情况来考虑成本效益比。
To investigate the effect of basal hormone levels including follicle stimulating hormone (FSH) and estradiol (E2) and age on the pregnancy outcomes in women undergoingin vitrofertilization and embryo transfer (IVF-ET), we designed a retrospective cohort analysis and collected information of patients undergoing IVF between January 2014 and April 2017. We found that young women had much better pregnancy outcomes than older women regardless of the hormone levels. The pregnancy outcomes declined in young women with high basal E2, even though they had normal FSH. Older women with higher FSH had a worse outcome of pregnancy, especially with increased E2level. The results suggest that a combination of FSH, E2and age could effectively predict the pregnancy outcome for women undergoing IVF-ET, and we should encourage infertile women with diminished ovarian reserve, especially young infertile women, to try the assisted reproduction as early as possible. After 40-yearold, the cost-benefit ratio should be considered according to the ovarian function.