Morphologic and physiologic effects of chemotherapeutic agents in psoriasis.
Morphologic and physiologic effects of chemotherapeutic agents in psoriasis.
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DOI：
10.1038/jid.1959.161
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发表时间：
1959-10
期刊：
影响因子：
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通讯作者：
E. J. V. Scott;Richard P. Reinertson
中科院分区：
文献类型：
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作者：
E. J. V. Scott;Richard P. Reinertson
几个世纪以来，无数治疗银屑病的经验性使用已经挑选出相对少量的药物或药剂，这些药物或药剂被认为具有有利地影响疾病的有价值的特性。其中最常用的包括紫外线、X射线、煤焦油衍生物以及汞和砷的化合物。这些药物有效的原因尚不清楚，尽管已经提出了各种解释。一个相当流行和可信的信念是，这些药物由于其毒性而影响银屑病的病变，由于其对细胞的一般毒性而抑制表皮增生。Gubner（1）观察到氨基蝶呤（一种具有抗肿瘤特性的叶酸拮抗剂）可导致银屑病皮疹的临床清除，这一点后来被Rees和班尼特（2）证实。然而，对这一假设的一个检验是确定在银屑病皮损愈合过程中，在使用不同的治疗有效药物后，表皮发生的组织学和细胞学变化是否相似，Burks和蒙哥马利（3）研究了银屑病患者的组织学变化，这些患者在局部应用焦油和紫外线照射治疗后的第10 - 14天取出标本。在这些标本中存在颗粒层;角质层正常或略微增厚，角化不全减少。
Empirical use of countless remedies for psoriasis over the centuries has sorted out a relatively small number of drugs or agents that are recog-nized as having the worthwhile property of favorably affecting the disease. The most commonly utilized of these include ultraviolet light, X-radiation, derivatives of coal tar, and compounds of mercury and arsenic. The reason for the effectiveness of these agents is unknown, although various explanations have been conjectured. A rather popular and credible belief has been that the agents affect the lesion of psoriasis by virtue of their poisonous nature, inhibiting epidermal hyperplasia because of their general toxicity to cells. The observation of Gubner (1), later verified in many patients by Rees and Bennett (2), that aminopterin, a folie acid antagonist having anti-tumor properties, can cause clinical clearing of the cutaneous eruption of psoriasis seems to be compatible with this belief. One test of the hypothesis, however, would be to determine whether the histologic and cytologic changes occurring in the epidermis during healing of the lesion of psoriasis are similar following the different therapeutically effective agents.Burks and Montgomery (3) studied the histo-logic changes of psoriasis in patients treated with topically-applied tar and ultraviolet light in specimens removed on the lOth—l4th day of this treatment. In these specimens a stratum granulo-sum was present; the stratum eorneum was nor-mal or slightly thickened, with diminished parakeratosis.