Convenient and Efficient Synthesis of 1,1‐Bis‐(4‐alkylthiophenyl)‐1‐alkenes via Tandem Friedel–Crafts Acylation and Alkylation of Sulfides and Acyl Chlorides
Convenient and Efficient Synthesis of 1,1‐Bis‐(4‐alkylthiophenyl)‐1‐alkenes via Tandem Friedel–Crafts Acylation and Alkylation of Sulfides and Acyl Chlorides
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DOI：
10.1080/00397910500187373
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发表时间：
2005-09
影响因子：
2.1
通讯作者：
Jiaxi Xu;Jia‐Dong Xia;Y. Lan
中科院分区：
文献类型：
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作者：
Jiaxi Xu;Jia‐Dong Xia;Y. Lan
摘要在无水三氯化铝存在下，以烷基苯硫醚和酰氯为原料，通过Friedel-Crafts酰基化和烷基化反应，方便、高效地合成了1，1-双（4-烷硫基苯基）-1-烯烃。并对串联反应的适用范围、局限性和机理进行了讨论。
Abstract 1,1‐Bis(4‐alkylthiophenyl)‐1‐alkenes were conveniently and efficiently prepared from alkyl phenyl sulfides and acyl chlorides via a tandem Friedel–Crafts acylation and alkylation in the presence of anhydrous aluminum chloride. The scope, limitation, and mechanism of the tandem reaction were also discussed.