Naltrexone for heroin dependence treatment in St. Petersburg, Russia
Naltrexone for heroin dependence treatment in St. Petersburg, Russia
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DOI：
10.1016/j.jsat.2004.02.002
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发表时间：
2004-06-01
影响因子：
3.9
通讯作者：
Woody, GE
中科院分区：
文献类型：
--
作者：
Krupitsky, EM;Zvartau, EE;Woody, GE
纳洛酮在俄罗斯治疗阿片类药物（海洛因）依赖可能比在美国更有效，因为患者大多年轻，与父母住在一起，他们可以控制药物依从性。在这项初步研究中，我们将52名同意在彼得堡完成戒毒的患者随机分为两组，一组接受为期6个月的双盲双周药物咨询和纳洛酮，另一组接受安慰剂纳洛酮。从第1个月开始并在整个研究中持续观察到有利于纳洛酮的保留和复发的显著差异。在6个月结束时，27名纳洛酮患者中有12名（44.4%）仍在治疗中，与25名安慰剂患者中的4名（16%; p < 0.05）相比，没有复发。由于海洛因依赖是艾滋病毒在俄罗斯传播的主要方式，如果能够更广泛地提供，纳洛酮可能会改善治疗结果并有助于减少艾滋病毒的传播。(C)2004年爱思唯尔公司All rights reserved.
Naltrexone may be more effective for treating opioid (heroin) dependence in Russia than in the U.S. because patients are mostly young and living with their parents, who can control medication compliance. In this pilot study we randomized 52 consenting patients who completed detoxification in St. Petersburg to a double blind, 6-month course of biweekly drug counseling and naltrexone, or counseling and placebo naltrexone. Significant differences in retention and relapse favoring naltrexone were seen beginning at I month and continuing throughout the study. At the end of 6 months, 12 of the 27 naltrexone patients (44.4%) remained in treatment and had not relapsed as compared to 4 of 25 placebo patients (16%; p < 0.05). Since heroin dependence is the main way HIV is being spread in Russia, naltrexone is likely to improve treatment outcome and help reduce the spread of HIV if it can be made more widely available. (C) 2004 Elsevier Inc. All rights reserved.