Stress during gestation induces lasting effects on emotional reactivity of the dam rat
Stress during gestation induces lasting effects on emotional reactivity of the dam rat
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DOI：
10.1016/j.bbr.2003.12.001
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发表时间：
2004-08-12
影响因子：
2.7
通讯作者：
Maccari, S
中科院分区：
文献类型：
--
作者：
Darnaudéry, M;Dutriez, I;Maccari, S
对人类和动物的研究表明，怀孕期间反复的压力会给后代造成长期的生物和行为障碍。相反，虽然母亲的压力应该会引起母亲的焦虑增加，很少有研究已经进行了证明it. Therefore，在本研究中，我们研究了情绪反应的压力（慢性约束压力施加3 × 45分钟，每天在怀孕的最后一周）和无压力的雌性大鼠断奶后，他们的幼崽。约束压力程序减少体重增加在怀孕期间和长达四周后的压力时期。应激母鼠暴露于新环境（应激后25天和49天）时，探索和皮质酮水平降低。他们在高架十字迷宫的开放臂上花费的时间更少（应激后26天）。最后，他们在第二次暴露于强迫游泳测试（压力后35-36天）后没有显示出不动时间的增加。相反，当慢性应激程序应用于处女雌性时，没有观察到这种差异。总的来说，我们的研究结果表明，在怀孕期间的慢性应激诱导持久的影响情绪C妊娠构成了一个关键时期的脆弱性，压力事件也为母亲。反应性的大坝，从而表明（C）2003爱思唯尔B. V.保留所有权利。
Human and animal studies indicate that repeated stress during pregnancy can produce long-term biological and behavioural disorders in the offspring. In contrast, although maternal stress is supposed to induce an increase of maternal anxiety, few studies have been conducted to demonstrate it. Therefore, in the present study we examined the emotional reactivity in stressed (chronic restraint stress applied 3 x 45 min per day during the last week of pregnancy) and unstressed females rats after the weaning of their pups. Restraint stress procedure reduced the body weight gain both during pregnancy and up to four weeks after the stress period. Stressed dams presented a reduction of exploration and of corticosterone levels when exposed to a novel environment (25 and 49 days post-stress). They spent less time in the open arms of the elevated plus-maze (26 days post-stress). Finally, they showed no increase in the time spent in immobility after a second exposure to the forced-swim test (35-36 days post-stress). In the contrary, such differences were not observed when the chronic stress procedure was applied on virgin females. Overall, our results show that, chronic stress during gestation induces lasting effects on emotional C gestation constitutes a critical period in the vulnerability to stressful events also for the mother. reactivity of the dams, thus indicating that (C) 2003 Elsevier B.V. All rights reserved.