Synthesis, structures, and electrochemistry of gold(III) ethylenediamine complexes and interactions with guanosine 5'-monophosphate.
Synthesis, structures, and electrochemistry of gold(III) ethylenediamine complexes and interactions with guanosine 5'-monophosphate.
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乙二胺金 (III) 配合物的合成、结构和电化学以及与 5-单磷酸鸟苷的相互作用。
DOI：
10.1021/ic051411p
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发表时间：
2006
影响因子：
4.6
通讯作者：
Walmsley,JudithA
中科院分区：
文献类型：
--
作者：
Zhu,Shourong;Gorski,Waldemar;Powell,DouglasR;Walmsley,JudithA
[Au(en)Cl2]Cl·2H2O, where en = ethylenediamine (1,2-diaminoethane), has been synthesized, and its structure has been solved for the first time by the single-crystal X-ray diffraction method. The complex has square-planar geometry about AuIII, and the anionic Cl-is located in the apical position and at a distance of 3.3033(10) Å compared to 2.2811(9) and 2.2836(11) Å for the coordinated Cl-. [Au(en)Cl2]Cl·2H2O belongs to the space groupPbcawitha= 11.5610(15) Å,b= 12.6399(17) Å,c= 13.2156(17) Å, α = β = γ = 90°, andZ= 8. Bond lengths of Au−N are 2.03 Å. [Au(en)Cl2]Cl·2H2O is less thermally stable than [Au(en)2]Cl3because of the replacement of two Cl ligands by a second en ligand in the latter. Cyclic voltammetry shows that the formal potential of AuIII/Au0becomes more negative in the series [AuCl4]-, [Au(en)Cl2]+, and [Au(en)2]3+.1H,13C, and31P NMR reveal that in an aqueous solution [Au(en)Cl2]+bonds to guanosine 5‘-monophosphate, 5‘-GMP (1:1 mole ratio), via N(7), although the stability is not very high. NMR data also indicate that N(7)−O(6) or N(7)−phosphate 5‘-GMP chelation, as found in some gold(III) nucleotide complexes, is not present. The gold(III) complex undergoes hydrolysis at pH >2.5−3.0 and, therefore, N1 coordination to 5‘-GMP is not observed. No direct coordination between 5‘-GMP and [Au(en)2]Cl3is observed.
