Association between sleep duration and depression in US adults: A cross-sectional study
Association between sleep duration and depression in US adults: A cross-sectional study
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DOI：
10.1016/j.jad.2021.09.075
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发表时间：
2021-10-01
影响因子：
6.6
通讯作者：
Zou, Xiaohua
中科院分区：
文献类型：
--
作者：
Dong, Lu;Xie, Yongwei;Zou, Xiaohua
背景：睡眠持续时间与抑郁症之间相关性的证据并不一致。方法：纳入 2009 年至 2016 年参加国家健康和营养检查调查 (NHANES) 的成年人。使用多变量逻辑回归来评估睡眠持续时间与抑郁之间的关联。结果：在本研究的 25,962 名参与者（平均年龄 48.1 岁；49.2% 男性）中，23,636 名参与者的抑郁评分 = 10。在调整性别、年龄、种族/民族、教育程度、婚姻状况和家庭年收入、BMI、饮酒状况和吸烟状况、高血压、糖尿病后， 血脂异常、工作活动和身体活动风险因素中，睡眠时间短的参与者发生抑郁症的比值比 (OR) 为 1.86（95% 置信区间 1.59, 2.17），睡眠时间长的参与者的比值比 (OR) 为 1.49（95% 置信区间 1.22, 1.83）。进一步的分析显示睡眠时间和抑郁症之间存在 U 形关联。当睡眠时间< 8小时时，增加睡眠时间与抑郁症风险显着降低相关（OR = 0.68 [95% CI 0.64, 0.71]，P < 0.001）。当睡眠时间 >= 8 小时时，抑郁风险随着睡眠时间的增加而显着增加（OR = 1.32 [95%CI 1.23, 1.41]，P < 0.001）。结论：睡眠时间与较高的抑郁发生率独立相关。不仅睡眠不足，睡眠过多也会增加患抑郁症的风险。
Background: Evidence of an association between sleep duration and depression was inconsistent.Methods: Adults who participated in the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2016 were included. Multivariable logistic regression was used to evaluate the association between sleep duration and depression.Results: Among the 25,962 participants (mean age 48.1 years; 49.2% male) in this study, 23,636 had a depression score = 10. After adjustment for gender, age, race/ethnicity, education, marital status, and annual family income, BMI, alcohol status, and smoking status, hypertension, diabetes, dyslipidemia, work activity, and physical activity risk factors, participants who had short sleep duration had odds ratios (OR) of 1.86 (95% confidence interval 1.59, 2.17) and participants who had long sleep duration had OR of 1.49 (95% confidence interval 1.22, 1.83) for incident depression. Further analysis revealed a U-shaped association between sleep duration and incident depression. When sleep duration < 8 hours, increased sleep duration is associated with a significantly lower risk of incident depression (OR = 0.68 [95% CI 0.64, 0.71], P < 0.001). When sleep duration >= 8 hours, the risk of depression increased significantly with an increase in sleep duration (OR = 1.32 [95%CI 1.23, 1.41], P < 0.001).Conclusions: Sleep duration were independently associated with a higher incident depression. Not only insufficient sleep but excessive sleep also increase the risk of depression.