Postoperative radiation performed at the same surgical facility associated with improved overall survival in oral cavity squamous cell carcinoma
Postoperative radiation performed at the same surgical facility associated with improved overall survival in oral cavity squamous cell carcinoma
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DOI：
10.1002/hed.25697
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发表时间：
2019-07-01
影响因子：
2.9
通讯作者：
Karam, Sana D.
中科院分区：
文献类型：
--
作者：
Amini, Arya;Stokes, William A.;Karam, Sana D.
本分析的目的是评估在同一机构进行术后放疗（PORT）是否预示着比在不同机构进行PORT更好的生存结局。方法患者在国家癌症数据库报告机构接受前期手术，然后在PORT接受手术。PORT编码为在与手术相同的机构或不同的机构进行。结果共纳入10 832例患者。在同一机构接受PORT的患者的5年总生存率（OS）较高：52.5% vs 48.4%（P < 0.001）。在多变量（HR，0.92; P = 0.01）和倾向评分匹配（风险比，0.90; P = 0.004）分析中，在同一机构进行的PORT与OS改善相关。结论头颈部恶性肿瘤患者在同一手术场所行PORT术的OS较好。
Background The purpose of this analysis is to evaluate whether postoperative radiotherapy (PORT) at the same facility as surgery portends to better survival outcomes compared to PORT given at a different facility. Methods Patients underwent upfront surgery at the National Cancer Database reporting facility followed by PORT. PORT was coded as performed at either the same facility or at a different facility as surgery. Results A total of 10 832 patients were selected. Five-year overall survival (OS) was higher in patients undergoing PORT at the same facility: 52.5% vs 48.4% (P < 0.001). PORT performed at the same facility was associated with improved OS under multivariate (HR, 0.92; P = 0.01) and propensity score matched (hazard ratio, 0.90; P = 0.004) analyses. Conclusions OS was better among patients with head and neck cancer who received PORT at the same facility as surgery.