Synthesis of carboxylic block copolymers via reversible addition fragmentation transfer polymerization for tooth erosion prevention.
Synthesis of carboxylic block copolymers via reversible addition fragmentation transfer polymerization for tooth erosion prevention.
复制标题
通过可逆加成断裂转移聚合合成羧基嵌段共聚物，用于预防牙齿侵蚀。
DOI：
10.1177/0022034514551609
复制
发表时间：
2014
影响因子：
7.6
通讯作者：
Kilpatrick-Liverman,L
中科院分区：
文献类型：
--
作者：
Lei,Y;Wang,T;Mitchell,JW;Qiu,J;Kilpatrick-Liverman,L
牙科专业人员看到越来越多的患者有明显的牙齿侵蚀迹象。目前用于解决该问题的方法通常利用氟化物的釉质保护益处。在这份报告中，开发了一种替代性的新嵌段共聚物，其具有亲水性聚丙烯酸（PAA）嵌段和疏水性聚（甲基丙烯酸甲酯）（PMMA）嵌段，以类似地减少酸性条件下牙釉质的矿物质损失。采用可逆加成断裂转移（RAFT）聚合法合成了PMMA-b-PAA嵌段共聚物。通过凝胶渗透色谱（GPC）和核磁共振氢谱（1H NMR）对其结构进行了表征。最终嵌段共聚物中丙烯酸（AA）的摩尔分数被精细地控制在0.25至0.94之间，并且PMMA-b-PAA的分子量（Mn）被控制在10 kDa至90 kDa之间。用紫外-可见光谱（UV-Vis）和傅里叶变换红外光谱（FTIR）研究了嵌段共聚物与羟基磷灰石（HAP）的结合性能。FTIR光谱证实了PMMA-b-PAA嵌段共聚物与HAP之间的键合是以桥联双齿键进行的。UV-Vis和FTIR光谱还表明，高聚合物浓度和低溶液pH有利于聚合物与HAP结合。通过原子吸收光谱法（AAS）定量评价了PMMA-b-PAA嵌段共聚物在抑制HAP矿物损失方面的防蚀功效。根据结果，与未受保护的样品相比，聚合物处理使钙释放量减少了27%至30%。扫描电子显微镜（SEM）观察表明，PMMA-b-PAA聚合物处理保护釉质免受酸侵蚀。这种新的两亲性嵌段共聚物具有很大的潜力，可以作为替代的非氟化物成分整合到牙膏或漱口水中，以减少牙齿侵蚀。
Dental professionals are seeing a growing population of patients with visible signs of dental erosion. The approach currently being used to address the problem typically leverages the enamel protection benefits of fluoride. In this report, an alternative new block copolymer with a hydrophilic polyacrylic acid (PAA) block and a hydrophobic poly(methyl methacrylate) (PMMA) block was developed to similarly reduce the mineral loss from enamel under acidic conditions. This series of PMMA-b-PAA block copolymers was synthesized by reversible addition fragmentation transfer (RAFT) polymerization. Their structures were characterized by gel permeation chromatography (GPC) and1H nuclear magnetic resonance (NMR) spectra. The molar fractions of acrylic acid (AA) in the final block copolymer were finely controlled from 0.25 to 0.94, and the molecular weight (Mn) of PMMA-b-PAA was controlled from 10 kDa to 90 kDa. The binding capability of the block copolymer with hydroxyapatite (HAP) was investigated by ultraviolet–visible spectroscopy (UV-Vis) and Fourier transform infrared (FTIR) spectroscopy. FTIR spectra confirmed that the PMMA-b-PAA block copolymer could bind to HAPviabridging bidentate bonds. Both UV-Vis and FTIR spectra additionally indicated that a high polymer concentration and low solution pH favored the polymer binding to HAP. The erosion-preventing efficacy of the PMMA-b-PAA block copolymer in inhibiting HAP mineral loss was quantitatively evaluated by atomic absorption spectroscopy (AAS). Based on the results, polymer treatment reduced the amount of calcium released by 27% to 30% in comparison with the unprotected samples. Scanning electron microscope (SEM) observations indicated that PMMA-b-PAA polymer treatment protected enamel from acid erosion. This new amphiphilic block copolymer has significant potential to be integrated into dentifrices or mouthrinses as an alternative non-fluoride ingredient to reduce tooth erosion.