Comparative semantic profiles in semantic dementia and Alzheimer's disease
Comparative semantic profiles in semantic dementia and Alzheimer's disease
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DOI：
10.1093/brain/awt165
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发表时间：
2013-08-01
期刊：
影响因子：
14.5
通讯作者：
Grossman, Murray
中科院分区：
文献类型：
--
作者：
Libon, David J.;Rascovsky, Katya;Grossman, Murray
患有语义变异的原发性进行性失语症(也称为语义性痴呆)和阿尔茨海默病的患者在语义记忆方面存在缺陷。然而，很少有比较研究来确定这些患者组是否有明显的语义记忆障碍。我们要求15名语义变异型原发性进行性失语患者和57名阿尔茨海默病患者判断彩色照片和印刷单词的语义类别成员，这些类别是熟悉的自然类别和人为类别的成员，我们将表现与灰质萎缩联系起来。我们发现，语义变异型原发性进行性失语症和阿尔茨海默病在这一任务中都受到了显著的损害。此外，语义变异型原发性进行性失语患者对自然物体的判断缺陷显著高于他们自己对人造物体的判断缺陷。语义变异型原发进行性失语和阿尔茨海默病都有包括部分左侧颞叶的萎缩。在语义变异型原发进行性失语患者中，对左侧颞叶腹侧和内侧部分的相关表现进行回归分析，而在阿尔茨海默病患者中，回归分析与左侧大脑半球这些腹侧和内侧颞区以及外侧颞顶区域的相关表现。我们的结论是，语义变异型原发性进行性失语和阿尔茨海默病在一个简单的类别成员判断任务中都显著受损，语义变异型原发性进行性失语对自然种类的选择性损害部分与左侧颞叶腹内侧部视觉联想皮质的病变有关。我们讨论了可能导致语义变异型原发性进行性失语的语义记忆缺陷的因素。
Patients with the semantic variant of primary progressive aphasia, also known as semantic dementia, and Alzheimer's disease have deficits in semantic memory. However, few comparative studies have been performed to determine whether these patient groups have distinct semantic memory impairments. We asked 15 patients with semantic variant primary progressive aphasia and 57 patients with Alzheimer's disease to judge semantic category membership of coloured photos and printed words that are members of familiar natural and manufactured categories, and we related performance to grey matter atrophy. We found that both semantic variant primary progressive aphasia and Alzheimer's disease are significantly impaired on this task. Moreover, patients with semantic variant primary progressive aphasia had a significantly more prominent deficit for natural objects than their own deficit judging manufactured objects. Both semantic variant primary progressive aphasia and Alzheimer's disease had atrophy that included portions of the left temporal lobe. Regression analyses related performance in semantic variant primary progressive aphasia to ventral and medial portions of the left temporal lobe, while regression analyses in Alzheimer's disease related performance to these ventral and medial temporal areas as well as lateral temporal-parietal regions in the left hemisphere. We conclude that both semantic variant primary progressive aphasia and Alzheimer's disease are significantly impaired in a simple category membership judgement task and the selective impairment for natural kinds in semantic variant primary progressive aphasia is related in part to disease in visual association cortex in ventral-medial portions of the left temporal lobe. We discuss factors that may contribute to the semantic memory deficit in semantic variant primary progressive aphasia.