Antiplasmodial halogenated monoterpenes from the marine red alga Plocamium cornutum
Antiplasmodial halogenated monoterpenes from the marine red alga Plocamium cornutum
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DOI：
10.1016/j.phytochem.2009.02.010
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发表时间：
2009-03-01
期刊：
影响因子：
3.8
通讯作者：
Beukes, Denzil R.
中科院分区：
文献类型：
--
作者：
Afolayan, Anthonia F.;Mann, Maryssa G. A.;Beukes, Denzil R.
在我们继续从南非海洋生物中寻找抗疟疾的先导物的过程中，我们已经检测了地方性海洋红藻Plocamium cornutum（Turner）Harvey的抗疟原虫有机提取物。两个新的和三个已知的卤代单萜的分离和它们的结构确定的标准光谱技术。3，7-二甲基-3，4-二氯-辛-1，5，7-三烯骨架是所有五种化合物共有的。有趣的是，带有7-二氯甲基取代基的化合物对氯喹敏感的恶性疟原虫株显示出显著更高的抗疟原虫活性。(C)2009爱思唯尔有限公司保留所有权利。
in our continuing search for antimalarial leads from South African marine organisms we have examined the antiplasmodial organic extracts of the endemic marine red alga Plocamium cornutum (Turner) Harvey. Two new and three known halogenated monoterpenes were isolated and their structures determined by standard spectroscopic techniques. The 3,7-dimethyl-3,4-dichloro-octa-1,5,7-triene skeleton is common to all five compounds. Interestingly, compounds bearing the 7-dichloromethyl substituent showed significantly higher antiplasmodial activity toward a chloroquine sensitive strain of Plasmodium falciparum. (C) 2009 Elsevier Ltd. All rights reserved.