Adherence to WCRF/AICR cancer prevention recommendations and risk of postmenopausal breast cancer.
Adherence to WCRF/AICR cancer prevention recommendations and risk of postmenopausal breast cancer.
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DOI：
10.1158/1055-9965.epi-13-0210
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发表时间：
2013-09
期刊：
影响因子：
--
通讯作者：
White E
中科院分区：
文献类型：
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作者：
Hastert TA;Beresford SA;Patterson RE;Kristal AR;White E
2007年，世界癌症研究基金会(WCRF)和美国癌症研究所(AICR)发布了八项与身体肥胖、体育锻炼和饮食有关的建议，旨在预防全球最常见的癌症。然而，关于满足这些建议与患特定癌症(包括乳腺癌)风险之间的关联的信息有限。我们实施了六项建议(与身体肥胖、体力活动、促进体重增加的食物、植物性食品、红肉和加工肉类以及酒精有关)，并在维生素和生活方式(VITAL)研究队列中进行了6.7年的随访，检查了它们与浸润性乳腺癌发病率的关系。参与者包括2000-2002年间30,797名绝经后妇女，年龄在50-76岁之间，没有乳腺癌病史。通过西华盛顿监测、流行病学和最终结果(SEER)数据库追踪乳腺癌(n=899)。与未满足建议的女性相比，至少满足五项建议的女性患乳腺癌的风险降低了60%(HR：0.4；95%CI：0.25-0.65；P趋势<；0.001)。按顺序删除与降低风险最不相关的个人建议的进一步分析表明，这种减少是由于满足了与身体脂肪、植物性食物和酒精相关的建议(符合这三项建议的HR：0.38；95%CI：0.25-0.58；P趋势与0.001)。符合WCRF/AICR的癌症预防建议，特别是与酒精、体脂和植物性食物有关的建议，与减少绝经后乳腺癌的发病率有关。更多地遵守WCRF/AICR癌症预防建议可以大大降低美国妇女绝经后乳腺癌的风险。
In 2007 the World Cancer Research Fund (WCRF) and American Institute for Cancer Research (AICR) released eight recommendations related to body fatness, physical activity and diet aimed at preventing the most common cancers worldwide. However, limited information exists on the association between meeting these recommendations and risks of specific cancers, including breast cancer. We operationalized six recommendations (related to body fatness, physical activity, foods that promote weight gain, plant foods, red and processed meats, and alcohol) and examined their association with invasive breast cancer incidence over 6.7 years of follow-up in the VITamins And Lifestyle (VITAL) study cohort. Participants included 30,797 post-menopausal women ages 50–76 years at baseline in 2000–2002 with no history of breast cancer. Breast cancers (n=899) were tracked through the Western Washington Surveillance, Epidemiology and End Results (SEER) database. Breast cancer risk was reduced by 60% in women who met at least five recommendations compared to those who met none (HR: 0.40; 95% CI: 0.25–0.65; Ptrend<0.001). Further analyses that sequentially removed individual recommendations least associated with reduced risk suggested that this reduction is due to meeting recommendations related to body fatness, plant foods and alcohol (HR for meeting vs. not meeting these three recommendations: 0.38; 95% CI: 0.25–0.58; Ptrend <0.001). Meeting the WCRF/AICR cancer prevention recommendations, specifically those related to alcohol, body fatness and plant foods, is associated with reduced post-menopausal breast cancer incidence. Increased adherence to the WCRF/AICR cancer prevention recommendations could substantially reduce post-menopausal breast cancer risk in US women.