Therapeutic apheresis in kidney diseases: an updated review.
Therapeutic apheresis in kidney diseases: an updated review.
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DOI：
10.1080/0886022x.2022.2073892
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发表时间：
2022-12
期刊：
影响因子：
3
通讯作者：
中科院分区：
文献类型：
--
作者：
除了传统的药物治疗外，治疗性单采术已成为原发性或继发性肾脏疾病和肾移植的免疫抑制剂的重要辅助或替代治疗选择。用于肾脏疾病的治疗性单采技术包括血浆置换、双重过滤血浆置换、免疫吸附和低密度脂蛋白单采。血浆置换仍然是主要的体外治疗方法。最近，越来越多的证据支持双重过滤血浆置换和免疫吸附的潜在益处，可以更特异、更有效地清除病原性抗体，同时减少副作用。然而，仍然需要更多的随机对照试验。低密度脂蛋白单采术也是复发性局灶节段性肾小球硬化症患者的重要补充治疗。本综述收集了最近研究的最新证据，重点讨论这些技术的具体优点和缺点，并比较它们之间的差异，以确定某些肾脏疾病的最佳治疗方案。
Besides conventional medical therapies, therapeutic apheresis has become an important adjunctive or alternative therapeutic option to immunosuppressive agents for primary or secondary kidney diseases and kidney transplantation. The available therapeutic apheresis techniques used in kidney diseases, including plasma exchange, double-filtration plasmapheresis, immunoadsorption, and low-density lipoprotein apheresis. Plasma exchange is still the leading extracorporeal therapy. Recently, growing evidence supports the potential benefits of double-filtration plasmapheresis and immunoadsorption for more specific and effective clearance of pathogenic antibodies with fewer side effects. However, more randomized controlled trials are still needed. Low-density lipoprotein apheresis is also an important supplementary therapy used in patients with recurrent focal segmental glomerulosclerosis. This review collects the latest evidence from recent studies, focuses on the specific advantages and disadvantages of these techniques, and compares the discrepancy among them to determine the optimal therapeutic regimens for certain kidney diseases.
DOI：
10.5500/wjt.v8.i5.178
发表时间：
2018-09-10
期刊：
World journal of transplantation
影响因子：
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作者：
Mella A;Gallo E;Messina M;Caorsi C;Amoroso A;Gontero P;Verri A;Maletta F;Barreca A;Fop F;Biancone L
通讯作者：
Biancone L