Novel insights into astrocyte-mediated signaling of proliferation, invasion and tumor immune microenvironment in glioblastoma
Novel insights into astrocyte-mediated signaling of proliferation, invasion and tumor immune microenvironment in glioblastoma
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对星形胶质细胞介导的胶质母细胞瘤增殖、侵袭和肿瘤免疫微环境信号的新见解
DOI：
10.1016/j.biopha.2020.110086
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发表时间：
2020
影响因子：
7.5
通讯作者：
Hong Shen
中科院分区：
文献类型：
--
作者：
Hao Zhang;Yulai Zhou;Biqi Cui;Zhixiong Liu;Hong Shen
胶质母细胞瘤（GBM）仍然是最具侵袭性的脑部癌症。预后不佳主要归因于肿瘤细胞周围的微环境。星形胶质细胞是胶质母细胞微环境的主要组成部分，在中枢神经系统中起着几种基本的生理作用。在GBM的发展过程中，肿瘤相关星形胶质细胞（TAA）直接接触GBM细胞，其激活星形胶质细胞以形成反应性星形胶质细胞，通过多种众所周知的信号通路促进肿瘤进展、增殖和迁移。值得注意的是，TAA还通过抑制免疫应答和增强肿瘤细胞的放化疗抗性来影响GBM细胞的行为。这些新的活性与GBM的治疗和预后密切相关。在这篇综述中，我们讨论了最近的进展，反应性星形胶质细胞的新功能，包括TAA-癌细胞的相互作用，参与免疫抑制调节的机制，和放化疗抗性。预计这些最新的TAAs实验或临床研究可能在不久的将来为GBM治疗提供有希望的方法。
Glioblastoma (GBM) continues to be the most aggressive cancer of the brain. The dismal prognosis is largely attributed to the microenvironment surrounding tumor cells. Astrocytes, the main component of the GBM microenvironment, play several fundamental physiological roles in the central nervous system. During the development of GBM, tumor-associated astrocytes (TAAs) directly contact GBM cells, which activate astrocytes to form reactive astrocytes, facilitating tumor progression, proliferation and migration through multiple well-understood signaling pathways. Notably, TAAs also influence GBM cell behaviors via suppressing immune responses and enhancing the chemoradiotherapy resistance of tumor cells. These new activities are closely linked with the treatment and prognosis of GBM. In this review, we discuss recent advances regarding new functions of reactive astrocytes, including TAA-cancer cell interactions, mechanisms involved in immunosuppressive regulation, and chemoradiotherapy resistance. It is expected that these updated experimental or clinical studies of TAAs may provide a promising approach for GBM treatment in the near future.