The AraC family transcriptional regulator Rv1931c plays a role in the virulence of Mycobacterium tuberculosis
The AraC family transcriptional regulator Rv1931c plays a role in the virulence of Mycobacterium tuberculosis
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DOI：
10.1128/iai.72.9.5483-5486.2004
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发表时间：
2004-09-01
影响因子：
3.1
通讯作者：
Colston, MJ
中科院分区：
文献类型：
--
作者：
Frota, CC;Papavinasasundaram, KG;Colston, MJ
分离出 AraC 同源物 Rv1931c 被破坏的结核分枝杆菌菌株。该突变株在巨噬细胞和小鼠感染模型中均表现出存活率降低，但与 Rv1931c 基因互补后存活率得以恢复。这些结果表明 Rv1931c 调节对结核分枝杆菌毒力很重要的基因。
A Mycobacterium tuberculosis strain disrupted in the AraC homologue Rv1931c was isolated. The mutant strain exhibited reduced survival both in macrophages and in a mouse infection model, with survival being restored on complementation with the Rv1931c gene. These results suggest that Rv1931c regulates genes important for virulence of M. tuberculosis.