Concise synthesis and enzymatic resolution of L-(+)-homophenylalanine hydrochloride.
Concise synthesis and enzymatic resolution of L-(+)-homophenylalanine hydrochloride.
复制标题
L-( )-高苯丙氨酸盐酸盐的简明合成和酶法拆分。
DOI：
10.1080/10242430210706
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
S. Malhotra
中科院分区：
文献类型：
--
作者：
Hua Zhao;R. G. Luo;D. Wei;S. Malhotra
通过简单的三步反应合成了N-乙酰基高苯丙氨酸乙酯。采用工业酶Alcalase对L-（+）-高苯丙氨酸盐酸盐进行动力学拆分，得到了98%ee的产物。与其它方法相比，该方法具有操作简单、经济、产物光学纯度高的优点。
The N-acetyl-homophenylalanine ethyl ester was synthesized by a simple three-step-reaction strategy. L-(+)-homophenylalanine hydrochloride with 98% ee was obtained through a kinetic resolution process using industrial enzyme alcalase. Compared with other methods, this strategy has the advantage of economical and simple procedure giving high product optical purity.