Outer Hair Cells and Electromotility
Outer Hair Cells and Electromotility
复制标题
DOI：
10.1101/cshperspect.a033522
复制
发表时间：
2019-07-01
影响因子：
5.4
通讯作者：
Ashmore, Jonathan
中科院分区：
文献类型：
--
作者：
Ashmore, Jonathan
哺乳动物耳蜗的外毛细胞（OHC）表现得像执行器：它们将能量馈送到耳蜗分区并决定听觉的整体机制。它们通过产生依赖于电压的轴向力来实现这一点。通过显微镜观察到的细胞长度的变化被称为“电运动性”。“OHC产生力的机制可以追溯到一种特定的蛋白质，普雷斯廷，它是转运蛋白超家族SLC 26的成员。这篇简短的评论将确定有关普雷斯廷的一些最新发现。虽然普雷斯廷的三级结构尚未确定，但在非哺乳动物物种中存在其同系物的结果表明，哺乳动物OHC中可能存在构象，它如何像转运蛋白一样发挥作用，以及它如何进化。
Outer hair cells (OHCs) of the mammalian cochlea behave like actuators: they feed energy into the cochlear partition and determine the overall mechanics of hearing. They do this by generating voltage-dependent axial forces. The resulting change in the cell length, observed by microscopy, has been termed "electromotility." The mechanism of force generation OHCs can be traced to a specific protein, prestin, a member of a superfamily SLC26 of transporters. This short review will identify some of the more recent findings on prestin. Although the tertiary structure of prestin has yet to be determined, results from the presence of its homologs in nonmammalian species suggest a possible conformation in mammalian OHCs, how it can act like a transport protein, and how it may have evolved.