Insecticide resistance in dengue vectors
Insecticide resistance in dengue vectors
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登革热媒介的杀虫剂抗药性
DOI：
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
W. Black
中科院分区：
文献类型：
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作者：
H. Ranson;Joseph Burhani;N. Lumjuan;W. Black
背景：大多数国家的登革热控制方案广泛依赖杀虫剂来控制这种疾病的蚊子媒介。
目的：本次审查的目的是描述目前的知识，登革热病媒的杀虫剂耐药性的程度和这种耐药性的控制活动的潜在影响。
研究方法：我们在Web of Science和PubMed中搜索了包括登革热媒介埃及伊蚊和白纹伊蚊对四种主要杀虫剂（有机氯、氨基甲酸酯、有机磷酸盐和拟除虫菊酯）耐药性数据的研究。从已发表的文献中提取非生物测定数据，并对用于获得、分析和解释该数据的方法进行了严格评价。重点放在登革热控制中最广泛使用的两类杀虫剂，即有机磷和拟除虫菊酯。还对利用生物化学和分子生物学手段进行抗药性监测进行了综述。
结果：66项研究符合我们的纳入标准，并上传到公共数据库（IRBase）。在已发表的研究中存在很大的地理偏见，近一半来自三个国家（泰国，印度和巴西）。生物测定数据表明，抗有机磷temephos和拟除虫菊酯是广泛的，在Ae。埃及和阻力也已报告在Ae。白纹伊蚊由于用于测量和报告抗药性的方法各不相同，以及缺乏对杀虫剂抗药性的流行病学后果的研究，评估杀虫剂抗药性对病媒控制的影响变得复杂。
结论：由于缺乏可公开获取的标准化数据集，无法确定许多登革热流行国家的杀虫剂抗药性水平，也没有对抗药性的业务影响进行研究，因此无法全面分析目前杀虫剂抗药性对登革热控制构成的全球威胁。然而，几个有积极的抗药性监测方案的国家表明，杀虫剂抗药性正在降低我们控制登革热病媒的能力。除非迅速执行有效的战略以减轻这些影响，否则这种情况可能会恶化。
Background: Most national dengue control programmes rely extensively on insecticides to control the mosquito vectors of this disease.
Objectives: The objective of this review is to describe current knowledge of the extent of insecticide resistance in dengue vectors and the potential impact of this resistance on control activities.
Methods: We searched Web of Science and PubMed for studies that included data on resistance to the four major classes of insecticides: organochlorines, carbamates, organophosphates and pyrethroids, in the dengue vectors Aedes aegypti and Aedes albopictus. Insecticide bioassy data were extracted from the published literature and the methods used to obtain, analyse and interpret this data were critically evaluated. Emphasis was placed on the two insecticide classes most widely used in dengue control, organophosphates and pyrethroids. The use of biochemical and molecular tools for resistance monitoring was also reviewed.
Results: 66 studies met our inclusion criteria and were uploaded on to a public databse (IRBase). There is a stong geographical bias in published studies with nearly half originating from three countries (Thailand, India and Brazil). Bioassay data demonstrates that resistance to the organophosphate temephos and to pyrethroids is widespread in Ae. aegypti and resistance has also been reported in Ae. albopictus. Assessing the impact of insecticide resistance on vector control is complicated by variations in the methodology used to measure and report resistance, and by the lack of studies into the epidemiological consequences of insecticicde resistance.
Conclusions: The lack of publicly accessible standardized data sets dcoumenting levels of insecticide resistance in many dengue endemic countries, and the absence of studies on the operational impact of resistance, preculdes a comprehensive analysis of the current global threat that insecticide resistance poses to dengue control. However, several countries with active resistance monitoring programmes have shown that insecticide resistance is reducing our ability to control dengue vectors. This situation is likely to worsen unless effective strategies are rapidly implemented to mitigate these effects.