EFFECT OF MATERNAL MALNUTRITION ON SURFACE-ACTIVITY OF FETAL LUNGS IN RATS
EFFECT OF MATERNAL MALNUTRITION ON SURFACE-ACTIVITY OF FETAL LUNGS IN RATS
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DOI：
10.1152/jappl.1975.39.4.535
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发表时间：
1975-01-01
影响因子：
3.3
通讯作者：
FARIDY, EE
中科院分区：
文献类型：
--
作者：
FARIDY, EE
在白化大鼠中研究了母体营养不良或胎儿肺生长和表面力的影响。怀孕的白化病大鼠分别接受随机鼠粮（对照组）、部分食物剥夺（摄入量为对照组的1/2）、完全食物剥夺4天（妊娠第3-7天、9-13天或17-21天）、低蛋白（8%）或无脂肪饮食。在妊娠第21天（剖宫产）或出生时（妊娠第22天）对胎儿肺进行研究。妊娠17-21天母体食物剥夺（FD）和妊娠期间低蛋白(L)饮食后的胎儿和新生儿体重和肺湿重/干重比（低细胞肺）显著降低。FD和LP显著提高了胎肺提取物的最小表面张力（.gamma.min）。这与每肺DNA表达的肺卵磷脂含量减少约35%有关。妊娠期越早的大鼠被剥夺4天的食物对胎儿的影响越小。在出生时。Min和肺卵磷脂含量均达到控制值。这种恢复发生在出生后（4-10小时）和第一次喂养之前。肺仍然很小，细胞较少。妊娠大鼠的营养状况明显影响胎肺的表面活性和生长。
The effects of maternal malnutrition or fetal lung growth and surface forces were studied in albino rats. Pregnant albino rats were subjected to either rat chow ad lib (controls), partial food deprivation (intake 1/2 that of the controls), complete food deprivation for 4 days (on gestation day 3-7, 9-13 or 17-21), low protein (8%) or fat free diets. The fetal lungs were studied on the 21st day of gestation (delivered by cesarean section) or at birth (gestation day 22). Fetuses and neonates after maternal food deprivation (FD) on the 17-21 day of pregnancy and after a low-protein (L) diet during pregnancy had significantly smaller body weight and lung wet or dry weight/body weight ratio (hypocellular lungs). The minimum surface tension (.gamma.min) of fetal lung extracts was significantly increased with FD and LP. This was associated with a reduction of about 35% in lung lecithin cortent, expressed per lung DNA. The earlier in pregnancy the rat was subjected to 4-day food deprivation the less the effect on the fetus. At birth the .gamma.min and the lung lecithin content reached control values. This recovery occurred after birth (at age 4-10 h) and prior to 1st feeding. The lungs remained small and hypocellular. The nutritional status of the pregnant rat apparently influences the surface activity and the growth of the fetal lung.