Macroporous bioceramics: A remarkable material for bone regeneration
Macroporous bioceramics: A remarkable material for bone regeneration
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DOI：
10.1177/0885328211406459
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发表时间：
2012-09-01
影响因子：
2.9
通讯作者：
Yeoh, Fei-Yee
中科院分区：
文献类型：
--
作者：
Lew, Kien-Seng;Othman, Radzali;Yeoh, Fei-Yee
本文综述了近年来大孔生物陶瓷在骨缺损修复方面的研究进展。多孔生物陶瓷由于其较大的表面积有利于与宿主组织形成更牢固的结合而受到人们的关注。多孔生物陶瓷的研究对于克服致密生物陶瓷与宿主组织之间形成的不利结合，特别是在修复骨缺损方面具有重要意义。已被广泛研究的大孔生物陶瓷包括羟基磷灰石、磷酸三钙、氧化铝和氧化锆。孔隙大小和内部连接对骨组织的生长速率有显著影响。骨生长的羟基磷灰石支架的最佳孔径被认为是300 mm。在多孔羟基磷灰石支架上的组织长入的初始阶段，孔之间的互连的存在是至关重要的。此外，β-磷酸三钙支架上的孔形成也允许生长因子和细胞的浸渍，以显着改善骨组织生长。在大孔氧化铝上观察到血管化组织的形成，但由于其生物惰性性质，在致密氧化铝的情况下没有发生。支架上的大孔氧化铝涂层能够改善整体机械性能，并且能够浸渍生物活性材料，从而提高骨生长速率。尽管氧化锆的生物惰性，多孔氧化锆是有用的设计支架与上级机械性能后，被涂覆生物活性材料。氧化锆中的孔被认为可以改善涂层系统上的骨生长。总之，尽管生物陶瓷中孔隙的形成可能对机械性能产生不利影响，但孔隙提供的优势在修复骨缺损中至关重要。
This review summarises the major developments of macroporous bioceramics used mainly for repairing bone defects. Porous bioceramics have been receiving attention ever since their larger surface area was reported to be beneficial for the formation of more rigid bonds with host tissues. The study of porous bioceramics is important to overcome the less favourable bonds formed between dense bioceramics and host tissues, especially in healing bone defects. Macroporous bioceramics, which have been studied extensively, include hydroxyapatite, tricalcium phosphate, alumina, and zirconia. The pore size and interconnections both have significant effects on the growth rate of bone tissues. The optimum pore size of hydroxyapatite scaffolds for bone growth was found to be 300 mm. The existence of interconnections between pores is critical during the initial stage of tissue ingrowth on porous hydroxyapatite scaffolds. Furthermore, pore formation on beta-tricalcium phosphate scaffolds also allowed the impregnation of growth factors and cells to improve bone tissues growth significantly. The formation of vascularised tissues was observed on macroporous alumina but did not take place in the case of dense alumina due to its bioinert nature. A macroporous alumina coating on scaffolds was able to improve the overall mechanical properties, and it enabled the impregnation of bioactive materials that could increase the bone growth rate. Despite the bioinertness of zirconia, porous zirconia was useful in designing scaffolds with superior mechanical properties after being coated with bioactive materials. The pores in zirconia were believed to improve the bone growth on the coated system. In summary, although the formation of pores in bioceramics may adversely affect mechanical properties, the advantages provided by the pores are crucial in repairing bone defects.