The association between body mass index and the risk of different gastrointestinal cancers: A protocol for an overview of systematic reviews.
The association between body mass index and the risk of different gastrointestinal cancers: A protocol for an overview of systematic reviews.
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DOI：
10.1097/md.0000000000013181
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发表时间：
2018-11
期刊：
影响因子：
1.6
通讯作者：
Tian J
中科院分区：
文献类型：
--
作者：
Ma X;Gao Y;Li J;Zhang D;Tian J
在过去的几十年里，我们生活方式的变化导致了全球超重（定义为体重指数[BMI]≥25 kg/m2）和肥胖（BMI≥30 kg/m2）的患病率显著增加，从而对个人健康造成了许多有害后果。 一些荟萃分析支持肥胖和不同胃肠道癌症之间的联系，但研究之间存在很大的异质性。我们将综合已发表的系统评价，以评价体重指数（BMI）与不同胃肠道癌症的发病率和死亡率之间的关系。将于2018年7月在PubMed、EMBASE和科克伦图书馆中系统检索系统综述、荟萃分析和汇总分析。两名综述作者将独立筛选标题和摘要的相关性，评估全文纳入，进行数据提取，并使用AMSTAR检查表评估方法学质量，使用PRISMA声明评估报告质量。通过计算汇总相对风险（RR）及其95%置信区间（CI）来估计BMI与不同胃肠道癌症之间的关联，RR及其95%置信区间（CI）将根据研究中提供的校正RR、比值比或风险比和95% CI计算。将使用I2统计量评估研究间的异质性，作为异质性导致的估计值总变异比例的指标，其中25%、50%和75%的I2值对应于低、中和高异质性程度的临界点。当存在显著异质性时，将使用随机效应模型作为合并方法，当未观察到异质性时，将使用固定效应模型。可能的发表偏倚将通过Begg和Egger检验进行检验。本系统综述将提供一个可访问的，全面的综合，告知临床医生和高BMI个体管理指南的发展。本研究仅使用已发表的次要数据，因此不需要伦理批准。PROSPERO注册号：CRD 42018107334。
Supplemental Digital Content is available in the text Changes in our lifestyle over the past few decades have led to a significant increase in the worldwide prevalence of both overweight (defined as a body mass index [BMI]≥25 kg/m2) and obesity (BMI≥30 kg/m2), thus leading to numerous harmful consequences for an individual's health. Several meta-analyses support the link between obesity and different gastrointestinal cancers, but substantial heterogeneity exists between studies. We will synthesize published systematic reviews to evaluate the association between body mass index (BMI) and the incidence and mortality of different gastrointestinal cancers. PubMed, EMBASE, and the Cochrane Library will be systematically searched for systematic reviews, meta-analyses, and pooled analyses in July, 2018. Two review authors will independently screen titles and abstracts for relevance, assess full texts for inclusion, carry out data extraction, and appraise methodological quality using AMSTAR checklist and reporting quality using PRISMA statement. The association between BMI and different gastrointestinal cancers will be estimated by computing the pooled relative risk (RR) and its 95% confidence interval (CI), which will be calculated from the adjusted RR, odds ratio, or hazard ratio, and 95% CI offered in the studies. Heterogeneity between studies will be assessed with the I2 statistic as a measure of the proportion of total variation in estimates that is due to heterogeneity, where I2 values of 25%, 50%, and 75% correspond to cut-off points for low, moderate, and high degrees of heterogeneity. The random effects model will be used as the pooling method when significant heterogeneity existed and the fixed effect model will be used when no heterogeneity was observed. Possible publication bias will be tested by Begg and Egger test. This overview of systematic reviews will provide an accessible, comprehensive synthesis with which to inform clinicians and the development of guidelines for the management of the individuals with high BMI. Only published secondary data will be used in this study, and therefore ethics approval is not required. PROSPERO registration number: CRD42018107334.