Amichalasines A-C: Three Cytochalasan Heterotrimers from Aspergillus micronesiensis PG-1
Amichalasines A-C: Three Cytochalasan Heterotrimers from Aspergillus micronesiensis PG-1
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Amichalasines A-C：来自密克罗尼曲霉 PG-1 的三种细胞松弛素异三聚体
DOI：
10.1021/acs.orglett.8b04066
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发表时间：
2019-02-15
期刊：
影响因子：
5.2
通讯作者：
Zhang, Yonghui
中科院分区：
文献类型：
--
作者：
Wu, Zhaodi;Tong, Qingyi;Zhang, Yonghui
Amichalasines A-C(1-3)是从密克罗尼西亚曲霉PG-1中分离得到的一种新型细胞松弛素异源三聚体。化合物1和2具有一个十一环的5/6/11/5/5/6/6/6/5/11/6/5环系，化合物3具有一个附加的呋喃环和一个十二环的5/6/11/5/5/6/6/5/5/11/6/5环系。1和2通过激活caspase-3和降解PARP诱导细胞凋亡，对HL60细胞的IC50值分别为1.71和3.74mU。
Amichalasines A-C (1-3), which represent a new type of cytochalasan heterotrimers, were isolated from Aspergillus micronesiensis PG-1. Compounds 1 and 2 possess an undecacyclic 5/6/11/5/5/6/6/5/11/6/5 ring system, and 3 has an additional furan ring with a dodecacyclic 5/6/11/5/5/6/6/5/5/11/6/5 ring system. 1 and 2 exhibited potent cytotoxic activities through apoptosis induction mediated by caspase-3 activation and PARP degradation, and their IC50 values against HL60 cells were 1.71 and 3.74 mu M, respectively.