Boundary integral method for bioluminescence tomography.
Boundary integral method for bioluminescence tomography.
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DOI：
10.1117/1.2191790
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发表时间：
2006-03
影响因子：
3.5
通讯作者：
W. Cong;Ge Wang
中科院分区：
文献类型：
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作者：
W. Cong;Ge Wang
生物发光断层扫描(BLT)可以在体内定位和量化小动物体内的生物发光源，以揭示各种分子和细胞活动。我们开发了一种重建方法来识别这样的生物发光源分布使用边界积分方法。该方法基于生物组织中光子传播的扩散模型，引入先验知识来定义允许的源区，并在测量的体表数据和未知的生物发光源分布之间建立直接的线性关系，以提高数值稳定性和效率。BLT算法在异质小鼠胸腔模型研究中的可行性得到了验证。
Bioluminescence tomography (BLT) allows in vivo localization and quantification of bioluminescent sources inside a small animal to reveal various molecular and cellular activities. We develop a reconstruction method to identify such a bioluminescent source distribution using the boundary integral method. Based on the diffusion model of the photon propagation in the biological tissue, this method incorporates a priori knowledge to define the permissible source region, and establish a direct linear relationship between measured body surface data and an unknown bioluminescent source distribution to enhance numerical stability and efficiency. The feasibility of the proposed BLT algorithm is demonstrated in heterogeneous mouse chest phantom studies.