Movement-related cortical potentials associated with progressive muscle fatigue in a grasping task
Movement-related cortical potentials associated with progressive muscle fatigue in a grasping task
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DOI：
10.1016/s1388-2457(00)00452-1
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发表时间：
2001-01-01
影响因子：
4.7
通讯作者：
Slobounov, S
中科院分区：
文献类型：
--
作者：
Johnston, J;Rearick, M;Slobounov, S
目的：本研究旨在进一步解决有关行为和神经生理指标和机制的一般性实证问题，这些指标和机制有助于和/或补偿肌肉疲劳。特别是，我们检查了等长力产生、肌电图和脑电图与受试者执行抓握任务时进行性肌肉疲劳的相关性。方法：使用特制的握力计，指导6名神经系统健康的受试者在120次试验中产生并保持70%的最大自愿收缩（MVC），共5 s。运动相关电位的三个组成部分（bereitschaftpotential， BP, Motor potential， MP和Movement-monitoring potential）。从连续脑电图记录中提取MMP，并参照肌肉疲劳行为指标进行分析。结果：实验操作引起肌肉疲劳，其表现为MVC值和平均力水平的降低，同时肌电均方根（RMS）振幅相对于基线水平和EMC斜率的增加。脑电数据显示中央前（Cz和FCz）和对侧（C3）电极的MP幅值显著增加，中央前（Cz和FCz）电极的BP幅值显著增加。结论：肌电信号振幅、肌电信号斜率和MP振幅的增加表明可能存在联系。源自运动皮层的控制信号与α -运动神经元池的活动水平之间作为进行性肌肉疲劳的函数。总的来说，数据表明，进行性肌肉疲劳诱导了辅助运动区和对侧感觉运动区皮层电激活的系统性增加，这反映在运动相关脑电图电位的振幅上。(C) 2001爱思唯尔科学爱尔兰有限公司版权所有。
Objective: The present research was aimed to further address the general empirical question regarding the behavioral and neurophysiological indices and mechanisms that contribute to and/or compensate for muscle fatigue. In particular, we examined isometric force production, EMG, and EEG correlates of progressive muscle fatigue while subjects performed a grasping task.Methods: Six neurologically healthy subjects were instructed to produce and maintain 70% of maximum voluntary contraction (MVC) for a total of 5 s in a sequence of 120 trials using a specially designed grip dynamometer. Three components of movement-related potentials (Bereitschaftspotential, BP, Motor potential, MP, and Movement-monitoring potential. MMP) were extracted from continuous EEG records and analyzed with reference to behavioral indicators of muscle fatigue.Results: Experimental manipulations induced muscle fatigue that was demonstrated by decreases in both MVC values and mean force levels produced concomitant to increases in EMG root mean square (RMS) amplitude with respect to baseline levels, and EMC slope. EEG data revealed a significant increase in MP amplitude at precentral (Cz and FCz) and contralateral (C3) electrode sites, and increases in BP amplitude at precentral (Cz and FCz) electrode sites.Conclusions: The increases in EMG amplitude, EMG slope, and MP amplitudes suggest a possible link. between the control signal originating in the motor cortex and activity level of the alpha -motoneuron pool as a function of progressive muscle fatigue. Overall, the data demonstrate that progressive muscle fatigue induced a systematic increase in the electrocortical activation over the supplementary motor and contralateral sensorimotor areas as reflected in the amplitude of movement-related EEG potentials. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.