Brain tumors induced by Rous sarcoma virus, Schmidt-Ruppin strain. 3. Morphology of brain tumors induced in adult mice.
Brain tumors induced by Rous sarcoma virus, Schmidt-Ruppin strain. 3. Morphology of brain tumors induced in adult mice.
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由劳斯肉瘤病毒 Schmidt-Ruppin 株诱导的脑肿瘤。
DOI：
10.1093/jnci/50.1.95
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发表时间：
1973
期刊：
影响因子：
--
通讯作者：
T. Yamamoto
中科院分区：
文献类型：
--
作者：
T. Kumanishi;F. Ikuta;T. Yamamoto
用产生劳斯肉瘤病毒Schmidt-Ruppin株的鸡肉瘤细胞脑内接种诱发的110例成年小鼠脑肿瘤进行了形态学观察。符合人类普通胶质瘤标准的典型胶质瘤一般在长潜伏期后诱发。组织学上属于胶质母细胞瘤、星形细胞瘤及其变异型。频率为总肿瘤的26%，约为接种后90天以上发展的肿瘤的50%。在400天的观察期内，主要由巨大圆形细胞组成的肿瘤最常见，并暂时命名为“巨大圆形细胞肿瘤”。频率约为总肿瘤的70%，约50%的肿瘤在90天后发展。根据光镜和电镜特征，推测其来源于胶质。无论是与这2个特征性肿瘤共存还是形成独立或离散的肿瘤，还观察到大细长的神经鞘瘤样（或成海绵细胞）和小梭形细胞。重点是在成年小鼠中成功诱导出典型的胶质瘤，以及频繁发生主要由巨大圆形细胞组成的、类似于人类胶质母细胞瘤的特异性巨大圆形细胞瘤。还讨论了每种脑瘤起源于小鼠而不是鸡的生化和生物学证据。
Morphologic examination was made on 110 brain tumors induced in adult mice by intracerebral inoculation with chicken sarcoma cells producing Schmidt-Ruppin strain of Rous sarcoma virus. The typical gliomas that satisfied the criteria of human ordinary glioma were, in general, induced after a long latency. Histologically, they belonged to glioblastoma, astrocytoma, and their variants. Frequency was 26% of the total tumors and was about 50% of the tumors that developed more than 90 days after inoculation. The tumors composed predominantly of huge round cells were most common throughout the observation period of 400 days and were tentatively designated “huge round-celled tumors.” Frequency was about 70% of the total tumors and about 50% of the tumors developing after 90 days. The glial origin of the huge round-celled tumor was su'ggested from its light and electron microscopical characteristics. Either coexisting with these 2 characteristic tumors or forming independent or discrete tumors, large elongated, neurinoma-like (or spongioblastic), and small spindle cells were also noted. Emphasis was given to the successful induction of the typical glioma in adult mice as well as to the frequent development of a cherccterlstlc huge round-celled tumor that was composed predominantly of huge round cells and resembled human gian.tcelled glioblastoma. Biochemical and biologic evidence for the mouse, not chicken, origin of each brain tumor was also discussed.