A silicon microelectrode array for simultaneous recording and stimulation in the brain of behaving animals
A silicon microelectrode array for simultaneous recording and stimulation in the brain of behaving animals
复制标题
DOI：
10.1109/iembs.2003.1279833
复制
发表时间：
2003-09
期刊：
影响因子：
--
通讯作者：
R. Olsson;D. Buhl;M. Gulari;G. Buzsáki;K. Wise
中科院分区：
文献类型：
--
作者：
R. Olsson;D. Buhl;M. Gulari;G. Buzsáki;K. Wise
本文介绍了一种集成CMOS电路的八通道硅神经探针，用于同时记录和刺激大脑。该探头包括八个片上放大器，可以单独旁路，允许直接进入铟位点进行电刺激。探头放大器的增益为38.9dB，截止频率上限为9.9 kHz，100 Hz至10 kHz范围内的输入参考噪声为9.2 /spl mu/Vrms。放大器的低频截止是可调的，以允许记录场电位并最小化刺激伪影。探针电路采用/spl plusmn/1.5 V电源供电，功耗为672 /spl mu/W，占用2.02 mm/sup 2/ in 3 /spl mu/m器件。体内记录表明，前置放大器可以在刺激开始后1 ms在接近刺激电极20 /spl mu/m的部位记录单个单位活动。通过精确调谐低频放大器截止，可以进一步抑制伪影。
This paper presents an eight-channel silicon neural probe with integrated CMOS circuitry designed for simultaneous recording and stimulation in the brain. The probe includes eight on-chip amplifiers that can be individually bypassed, allowing direct access to the indium sites for electrical stimulation. The on-probe amplifiers have a gain of 38.9dB, an upper cutoff frequency of 9.9 kHz, and an input referred noise of 9.2 /spl mu/Vrms from 100 Hz to 10 kHz. The low-frequency cutoff of the amplifier is tunable to allow the recording of field potentials and minimize stimulus artifact. The on-probe circuitry consumes 672 /spl mu/W from /spl plusmn/1.5 V supplies and occupies 2.02 mm/sup 2/ in 3 /spl mu/m features. In-vivo recordings have shown that the preamplifiers can record single-unit activity 1 ms after the onset of stimulation on sites as close as 20 /spl mu/m to the stimulating electrode. Further artifact suppression is achievable with precise tuning of the low-frequency amplifier cutoff.