Retino-hypothalamic regulation of light-induced murine sleep.
Retino-hypothalamic regulation of light-induced murine sleep.
复制标题
DOI：
10.3389/fnsys.2014.00135
复制
发表时间：
2014
影响因子：
3
通讯作者：
Heller HC
中科院分区：
文献类型：
--
作者：
Muindi F;Zeitzer JM;Heller HC
睡眠的时间组织是由生物钟和体内平衡过程之间的相互作用来调节的。光通过其相移和缠绕生物钟的能力间接调节睡眠。光也可以对睡眠产生直接的、不依赖于昼夜节律的影响。例如，急性暴露在光线下会促进夜间动物的睡眠和白天动物的觉醒。光直接影响睡眠和唤醒的机制还不是很清楚。在这篇综述中，我们讨论了光对啮齿动物视网膜和下丘脑水平的睡眠的直接影响。我们回顾了最近发表的小鼠数据，这些数据显示了视杆、视锥和基于黑素的光接收在光诱导睡眠的启动和维持中的作用。我们还提出了关于下丘脑机制的假说，这些假说已经被提出来解释光对睡眠的急性控制。特别是，我们回顾了最近评估腹外侧视前区(VLPO)和视交叉上核(SCN)的作用的研究。我们还讨论了光如何分别在夜间和白天动物中促进睡眠和唤醒。最后，我们建议对这一仍处于早期阶段的主题进行研究的新途径。
The temporal organization of sleep is regulated by an interaction between the circadian clock and homeostatic processes. Light indirectly modulates sleep through its ability to phase shift and entrain the circadian clock. Light can also exert a direct, circadian-independent effect on sleep. For example, acute exposure to light promotes sleep in nocturnal animals and wake in diurnal animals. The mechanisms whereby light directly influences sleep and arousal are not well understood. In this review, we discuss the direct effect of light on sleep at the level of the retina and hypothalamus in rodents. We review murine data from recent publications showing the roles of rod-, cone- and melanopsin-based photoreception on the initiation and maintenance of light-induced sleep. We also present hypotheses about hypothalamic mechanisms that have been advanced to explain the acute control of sleep by light. Specifically, we review recent studies assessing the roles of the ventrolateral preoptic area (VLPO) and the suprachiasmatic nucleus (SCN). We also discuss how light might differentially promote sleep and arousal in nocturnal and diurnal animals respectively. Lastly, we suggest new avenues for research on this topic which is still in its early stages.