THE DROSOPHILA PS2 ANTIGEN IS AN INVERTEBRATE INTEGRIN THAT, LIKE THE FIBRONECTIN RECEPTOR, BECOMES LOCALIZED TO MUSCLE ATTACHMENTS
THE DROSOPHILA PS2 ANTIGEN IS AN INVERTEBRATE INTEGRIN THAT, LIKE THE FIBRONECTIN RECEPTOR, BECOMES LOCALIZED TO MUSCLE ATTACHMENTS
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DOI：
10.1016/0092-8674(87)90580-0
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发表时间：
1987-12-24
期刊：
影响因子：
64.5
通讯作者：
WILCOX, M
中科院分区：
文献类型：
--
作者：
BOGAERT, T;BROWN, N;WILCOX, M
我们建立了位置特异性抗原2（PS2），果蝇细胞表面糖蛋白复合物，是脊椎动物纤维连接蛋白受体（整联蛋白）家族的无脊椎动物成员。新的单克隆抗体显示在果蝇胚胎和幼虫中PS2 α。亚基的大小为ca。140 kd。cDNA和基因组克隆的分析揭示了典型的PS2 α。亚基含有1394个氨基酸，并与整联蛋白α的重链和轻链具有广泛的同源性。亚单位。PS2抗原的分布在PS2 α水平上受到调节。亚基mRNA。在果蝇发育的早期，这种蛋白质仅限于中胚层，似乎与肌肉附着有关。我们认为，PS2，像脊椎动物纤连蛋白受体，介导的细胞形状和细胞-细胞外基质粘附的变化结合到基底膜蛋白。
We establish that the position-specific antigen 2 (PS2), a Drosophila cell surface glycoprotein complex, is an invertebrate member of the vertebrate fibronectin receptor (integrin) family. New monoclonal antibodies show that in Drosophila embryos and larvae PS2 .alpha. subunits have a size of ca. 140 kd. Analysis of cDNA and genomic clones revealed that the canonical PS2 .alpha. subunit contains 1394 amino acids and has extensive homology to the heavy and light chains of integrin .alpha. subunits. The distribution of the PS2 antigen is regulated at the level of PS2 .alpha. subunit mRNA. In early Drosophila development the protein is restricted to mesoderm and appears to be involved in muscle attachment. We suggest that PS2, like vertebrate fibronectin receptors, mediates changes in cell shape and cell-extracellular matrix adhesion by binding to a basement membrane protein.