DILIMOT: discovery of linear motifs in proteins.
DILIMOT: discovery of linear motifs in proteins.
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DOI:
10.1093/nar/gkl159
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发表时间:
2006-07-01
影响因子:
14.9
通讯作者:
Russell RB
中科院分区:
文献类型:
--
作者:
Neduva V;Russell RB
Discovery of protein functional motifs is critical in modern biology. Small segments of 3–10 residues play critical roles in protein interactions, post-translational modifications and trafficking. DILIMOT (DIscovery of LInear MOTifs) is a server for the prediction of these short linear motifs within a set of proteins. Given a set of sequences sharing a common functional feature (e.g. interaction partner or localization) the method finds statistically over-represented motifs likely to be responsible for it. The input sequences are first passed through a set of filters to remove regions unlikely to contain instances of linear motifs. Motifs are then found in the remaining sequence and ranked according to a statistic that measure over-representation and conservation across homologues in related species. The results are displayed via a visual interface for easy perusal. The server is available at
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影响因子:
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Neduva V;Linding R;Su-Angrand I;Stark A;de Masi F;Gibson TJ;Lewis J;Serrano L;Russell RB
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