AIDS dementia complex.
AIDS dementia complex.
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DOI：
10.1080/01947648809513542
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发表时间：
1988-12
期刊：
影响因子：
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通讯作者：
L. Prockop
中科院分区：
文献类型：
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作者：
L. Prockop
人类免疫缺陷病毒1型（HIV-1）感染产生一种总是致命的疾病，其中目前的治疗和管理仅提供症状的改善和死亡的延迟。残疾和死亡是由体质性疾病、神经系统疾病、继发性感染、继发性癌症和艾滋病毒感染或免疫抑制引起的其他病症造成的。神经系统疾病提供了特殊的医疗，法律的，和生物伦理问题和问题，因为它们会导致痴呆症，即在以前存在的智力功能水平下降。这些问题包括保密、知情同意、对有潜在危险但无疗效的诊断和治疗方式进行风险评估，以及非自愿限制或隔离。艾滋病痴呆综合症，其中痴呆是由于部分或全部直接影响的病毒对大脑，而不是机会性感染或继发性癌症，提供了一个重点考虑这些问题。
Infection with Human Immunodeficiency Virus Type 1 (HIV-1) produces an invariably fatal disease in which present therapies and management provide only amelioration of symptoms and delay of death. Disability and death are caused by constitutional disease, neurological disease, secondary infections, secondary cancers, and other conditions attributed to HIV infection or immunosuppression. Neurological conditions provide special medical, legal, and bioethical issues and problems because they cause dementia, ie, a decline in a previously existing level of intellectual function. The issues include confidentiality, informed consent, risk assessment of potentially dangerous but non-curative diagnostic and therapeutic modalities, and involuntary restraint or quarantine. The AIDS dementia complex, in which dementia is due partially or totally to a direct effect of the virus on the brain rather than to opportunistic infection or secondary cancer, provides a focus for consideration of these issues.