Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample
Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample
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DOI：
10.1016/j.drugalcdep.2007.08.015
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发表时间：
2008-01-11
影响因子：
4.2
通讯作者：
Bierut, Laura J.
中科院分区：
文献类型：
--
作者：
Agrawal, Arpana;Hinrichs, Anthony L.;Bierut, Laura J.
对酒精和非法药物的依赖经常同时发生。一些双胞胎研究的结果表明，酒精依赖和药物依赖的遗传影响可能基本上重叠。使用大型的，遗传信息丰富的家系，从酒精中毒遗传学合作研究（COGA），我们进行了定量连锁分析，使用一组1717个SNP。对DSM-IV酒精依赖标准、大麻依赖标准和任何非法药物（包括大麻）的依赖标准的定量措施进行了全基因组关联分析，单独和组合作为酒精和非法药物依赖标准的平均得分。对于酒精依赖，在1号染色体（213 cM处为2.0）、2号染色体（234 cM处为3.4）和10号染色体（60 cM处为3.7）上观察到LOD评分超过2.0。对于大麻依赖，在14号染色体上95 cM处注意到最大LOD为1.9。对于任何非法药物依赖，在10号染色体（116 cM）和13号染色体（64 cM）上分别观察到2.0和2.4的LOD。最后，合并的酒精和/或药物依赖症状在染色体2（3.2，234 cM）、10（60 cM和116 cM处为2.4和2.6）和13（64 cM处为2.1）上产生LOD>2.0。这些区域可能含有有助于酒精和药物依赖的生物学基础的基因。(c)2007爱思唯尔爱尔兰有限公司保留所有权利。
Dependence on alcohol and illicit drugs frequently co-occur. Results from a number of twin studies suggest that heritable influences on alcohol dependence and drug dependence may substantially overlap. Using large, genetically informative pedigrees from the Collaborative Study on the Genetics of Alcoholism (COGA), we performed quantitative linkage analyses using a panel of 1717 SNPs. Genome-wide linkage analyses were conducted for quantitative measures of DSM-IV alcohol dependence criteria, cannabis dependence criteria and dependence criteria across any illicit drug (including cannabis) individually and in combination as an average score across alcohol and illicit drug dependence criteria. For alcohol dependence, LOD scores exceeding 2.0 were noted on chromosome 1 (2.0 at 213 cM), 2 (3.4 at 234 cM) and 10 (3.7 at 60 cM). For cannabis dependence, a maximum LOD of 1.9 was noted at 95 cM on chromosome 14. For any illicit drug dependence, LODs of 2.0 and 2.4 were observed on chromosome 10 (116 cM) and 13 (64 cM) respectively. Finally, the combined alcohol and/or drug dependence symptoms yielded LODs >2.0 on chromosome 2 (3.2, 234 cM), 10 (2.4 and 2.6 at 60 cM and 116 cM) and 13 (2.1 at 64 cM). These regions may harbor genes that contribute to the biological basis of alcohol and drug dependence. (c) 2007 Elsevier Ireland Ltd. All rights reserved.